| Multiple myeloma presenting with recurrent hypercalcemia in a patient with a history of primary hyperparathyroidism: report of case and review of literature. | |
| | |
MedLine Citation:
|
PMID: 15760779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To report a case of primary hyperparathyroidism (PHPT) that presented with recurrent hypercalcemia due to multiple myeloma after successful parathyroidectomy. METHODS: The initial manifestations, investigations, and postoperative follow-up of a case of hypercalcemia due to PHPT are described. The studies performed for evaluation for recurrent hypercalcemia and the subsequent diagnosis of multiple myeloma are discussed. The association between these disorders and reports of similar cases in the literature are reviewed. RESULTS: A 72-year-old woman was referred for incidentally discovered hypercalcemia. She had no history of kidney stones or fractures. Further investigations revealed a high parathyroid hormone (PTH) level, hypercalciuria, and low bone mass, particularly at the cortical sites. Parathyroidectomy was performed, and a right inferior parathyroid adenoma was removed. Postoperatively, both the calcium and PTH levels normalized. She presented 9 months later with a 3-week history of pain in her left hip, polyuria, nausea, and vomiting. The patient had severe hypercalcemia and a suppressed PTH level. Further investigations revealed multiple bony lytic lesions, abnormalities on serum protein electrophoresis, and features consistent with multiple myeloma on a bone marrow biopsy specimen. CONCLUSION: Hypercalcemia can occur in patients with PHPT and multiple myeloma; however, the occurrence of both disorders in the same patient is rare. Review of the literature revealed only a few cases similar to ours. Evidence in the literature suggests that monoclonal gammopathies occur more often in patients with PHPT than in the general population; therefore, screening for monoclonal gammopathy may be warranted in patients with PHPT. |
| | |
Authors:
|
Hasnain M Khandwala; Markham A Boctor |
Related Documents
:
|
22184529 - Two cases of aspergillus endocarditis in non neutropenic children on chemotherapy for a... 818989 - Iris nodules in essential iris atrophy. 6657539 - Ige myeloma associated with plasma cell leukaemia. 23109209 - Benign pulmonary metastasizing leiomyoma uteri. case report and review of literature. 13460739 - Multiple myeloma; a review of 26 cases. 15727239 - Devic's neuromyelitis optica and mitochondrial dna mutation: a case report. 19046589 - The syndrome of irreversible lithium-effectuated neurotoxicity (silent): one-year follo... 12533389 - First branchial cleft anomaly presenting as a recurrent post-auricular abscess. 8275569 - Ambras syndrome: delineation of a unique hypertrichosis universalis congenita and assoc... |
Publication Detail:
|
Type: Case Reports; Journal Article; Review |
Journal Detail:
|
Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: 10 ISSN: 1530-891X ISO Abbreviation: Endocr Pract Publication Date: 2004 Jul-Aug |
Date Detail:
|
Created Date: 2005-03-11 Completed Date: 2005-04-21 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: United States |
Other Details:
|
Languages: eng Pagination: 345-7 Citation Subset: IM |
Affiliation:
|
Department of Medicine and the Division of Endocrinology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Female Humans Hypercalcemia / etiology* Hyperparathyroidism / blood, complications*, surgery Multiple Myeloma / blood, complications, diagnosis* Parathyroidectomy Recurrence |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reversible renal insufficiency attributable to thyroid hormone withdrawal in a patient with type 2 d...
Next Document: Some clues and pitfalls in the diagnosis of acromegaly.