Document Detail

Multiple myeloma in Ethiopians: analysis of 22 cases.
MedLine Citation:
PMID:  1396616     Owner:  NLM     Status:  MEDLINE    
Twenty-two cases of multiple myeloma were seen in the Department of Internal Medicine, Tikur Anbessa (Black Lion) Hospital, a teaching and referral hospital in Addis Abeba, Ethiopia, from January 1983 to December 1990. The age range was 38 to 76 (mean +/- SD = 51.5 +/- 12.2) years; a third were in the fifth decade. The male:female ratio was 1.75:1. The common clinical findings were bone pain in 20 (91%), bone tenderness in 15 (68%), anaemia in 14 (64%) and spinal cord compression in 8 (36%). The erythrocyte sedimentation rate (ESR) was raised in 21. Serum protein was raised in 17 (77%) and hyperglobulinaemia was seen in 20 (91%). Serum uric acid, blood urea nitrogen (BUN) and calcium were elevated in 10, 8 and 5 patients respectively, Bence-Jones proteinuria and albuminuria were each found in 9 patients. All patients had radiological abnormalities; 9 had a combination of lytic lesions, osteoporosis and pathological fractures (41%). Ten patients presented in clinical stage III. Four patients are being followed after 3-84 (median 40.5) months; eight were lost to follow-up 1-8 (median 2.0) months after diagnosis. Ten patients have died after 1-55 (median 11) months. Multiple myeloma is not uncommon in Ethiopians. Except for a lower age at presentation, the clinical, haematological, biochemical, and radiological findings, and the response to therapy, are similar to those reported elsewhere.
M Shamebo; R Tekle-Haimanot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ethiopian medical journal     Volume:  30     ISSN:  0014-1755     ISO Abbreviation:  Ethiop. Med. J.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-11-19     Completed Date:  1992-11-19     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  0373223     Medline TA:  Ethiop Med J     Country:  ETHIOPIA    
Other Details:
Languages:  eng     Pagination:  143-9     Citation Subset:  IM    
Department of Internal Medicine, Faculty of Medicine, Addis Abeba University, Ethiopia.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Combined Modality Therapy
Ethiopia / epidemiology
Hospitals, Teaching
Middle Aged
Multiple Myeloma* / diagnosis,  epidemiology,  therapy
Prospective Studies
Radiotherapy / standards
Survival Rate
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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