| Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on stillbirths and on early and late neonatal mortality. | |
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MedLine Citation:
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PMID: 20120796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Multiple micronutrient deficiencies are common among women in low-income countries and may adversely affect pregnancy outcomes. OBJECTIVE: To conduct a meta-analysis of the effects on stillbirths and on early and late neonatal mortality of supplementation during pregnancy with multiple micronutrients compared with iron-folic acid in recent randomized, controlled trials. METHODS: Twelve randomized, controlled trials were included in the analysis (Bangladesh; Burkina Faso; China; Guinea-Bissau; Indramayu and Lombok, Indonesia; Mexico; Sarlahi and Janakur, Nepal; Niger; Pakistan; and Zimbabwe), all providing approximately 1 recommended dietary allowance (RDA) of multiple micronutrients or iron-folic acid to presumed HIV-negative women. RESULTS: Supplementation providing approximately I RDA of multiple micronutrients did not decrease the risk of stillbirth (OR = 1.01; 95% CI, 0.88 to 1.16), early neonatal mortality (OR = 1.23; 95% CI, 0.95 to 1.59), late neonatal mortality (OR = 0.94; 95% CI, 0.73 to 1.23), or perinatal mortality (OR = 1.11; 95% CI, 0.93 to 1.33). CONCLUSIONS: Our meta-analysis provides consistent evidence that supplementation providing approximately 1 RDA of multiple micronutrients during pregnancy does not result in any reduction in stillbirths or in early or late neonatal deaths compared with iron-folic acid alone. |
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Authors:
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Carine Ronsmans; David J Fisher; Clive Osmond; Barrie M Margetts; Caroline H D Fall; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Food and nutrition bulletin Volume: 30 ISSN: 0379-5721 ISO Abbreviation: Food Nutr Bull Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-03-11 Revised Date: 2011-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7906418 Medline TA: Food Nutr Bull Country: Japan |
Other Details:
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Languages: eng Pagination: S547-55 Citation Subset: IM |
Affiliation:
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London School of Hygiene and Tropical Medicine, London, UK. Carine.ronsmans@lshtm.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Developing Countries
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statistics & numerical data* Dietary Supplements* Female Fetal Mortality Folic Acid / administration & dosage Humans Infant Mortality* Infant, Newborn Iron / administration & dosage Maternal Nutritional Physiological Phenomena* Micronutrients / administration & dosage*, deficiency Pregnancy Pregnancy Complications / drug therapy, prevention & control Pregnancy Outcome* Randomized Controlled Trials as Topic Stillbirth |
| Grant Support | |
ID/Acronym/Agency:
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U.1475.00.004.00005.01 (85821)//Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Micronutrients; 59-30-3/Folic Acid; 7439-89-6/Iron |
| Investigator | |
Investigator/Affiliation:
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Pierre Adou / ; Victor M Aguayo / ; Lindsay H Allen / ; Zulfiqar Ahmed Bhutta / ; Parul Christian / ; Shaonong Dang / ; Gwenola Desplats / ; Michael Dibley / ; Shams El Arifeen / ; Caroline Fall / ; David Fisher / ; Henrik Friis / ; Exnevia Gomo / ; Batool Azra Haider / ; Adi Hidayat / ; Abbas Jahari / ; Pernille Kaestel / ; Patrick Kolsteren / ; Kusharisupeni / ; Aissa Mamadoultaibou / ; Dharma Sharna Mandandhar / ; Barrie Margetts / ; Clive Osmond / ; David Osrin / ; Lars Ake Persson / ; Usha Ramakrishnan / ; Dominique Roberfroid / ; Carine Ronsmans / ; Anuraj H Shankar / ; Subarkah / ; Sunawang / ; Budi Utomo / ; Anjana Vaidya / ; Hong Yan / ; Noel Zagre / ; Lingxia Zeng / |
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