| Multiple microbial exposures in the home may protect against asthma or allergy in childhood. | |
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MedLine Citation:
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PMID: 20412140 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Experimental animal data on the gram-negative bacterial (GNB) biomarker endotoxin suggest that persistence, dose, and timing of exposure are likely to influence its effects on allergy and wheeze. In epidemiologic studies, endotoxin may be a sentinel marker for a microbial milieu, including gram-positive bacteria (GPB) as well as GNB, that may influence allergy and asthma through components (pathogen-associated molecular patterns) that signal through innate Toll-like receptor pathways. OBJECTIVE: To determine the influence of current GNB and GPB exposures on asthma and allergic sensitization in school-aged children. METHODS: We examined the relationship between bacterial biomarkers and current asthma and allergic sensitization in 377 school-aged children in a birth cohort study. We then evaluated the effects of school-aged endotoxin, after controlling for exposure in early life. RESULTS: Exposure to GNB was inversely associated with asthma and allergic sensitization at school age [for >median endotoxin: prevalence odds ratio (POR)=0.34, 95% CI=0.2-0.7, for current asthma and prevalence ratio=0.77, 95% CI=0.6-0.97, for allergic sensitization]. In contrast, elevated GPB in the bed was inversely associated with current asthma (POR=0.41, 95% CI=0.2-0.9) but not with allergic sensitization (POR=1.07, 95% CI=0.8-1.4). School-aged endotoxin exposure remained protective in models for allergic disease adjusted for early-life endotoxin. CONCLUSION: Both GNB and GPB exposures are associated with decreased asthma symptoms, but may act through different mechanisms to confer protection. Endotoxin exposure in later childhood is not simply a surrogate of early-life exposure; it has independent protective effects on allergic disease. |
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Authors:
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J E Sordillo; E B Hoffman; J C Celedón; A A Litonjua; D K Milton; D R Gold |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-04-13 |
Journal Detail:
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Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 40 ISSN: 1365-2222 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-18 Completed Date: 2010-10-14 Revised Date: 2013-04-26 |
Medline Journal Info:
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Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
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Languages: eng Pagination: 902-10 Citation Subset: IM |
Affiliation:
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Channing Laboratory, Boston, MA, USA. rejoa@channing.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allergens
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immunology Asthma* / epidemiology, immunology, prevention & control Child Child, Preschool Cohort Studies Dust / immunology Endotoxins / immunology* Environmental Exposure* Female Gram-Negative Bacteria / immunology Gram-Positive Bacteria / immunology Housing* Humans Hypersensitivity* / epidemiology, immunology, prevention & control Male Muramic Acids / immunology |
| Grant Support | |
ID/Acronym/Agency:
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AI35786/AI/NIAID NIH HHS; ES07036/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Dust; 0/Endotoxins; 0/Muramic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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