Document Detail

Multiple mRNA species for the precursor to an adenovirus-encoded glycoprotein: identification and structure of the signal sequence.
MedLine Citation:
PMID:  6985478     Owner:  NLM     Status:  MEDLINE    
Early region 3 of the adenovirus type 2 genome encodes three proteins with molecular weights of 16,000, 14,500, and 14,000 (E2/16, E3/14.5, and E3/14). The E3/16 protein is the precursor to the E3/19 glycoprotein and is around 1500 daltons larger than the unglycosylated E3/19O protein. The E3/14.5 and E3/14 proteins are structurally related to each other but different from E3/16. Three mRNA species were identified for E3/16; all have common 5' ends with the same spliced region but with different 3' ends. E3/14 was translated from a 13S mRNA with the same 5' structure as the E3/16 mRNA but followed by a second spliced region with a different 3' end. A partial amino acid sequence was determined for E3/16 after radioactive labeling in vitro and this sequence can be aligned with a known DNA sequence. It contains a hydrophobic signal sequence, two presumptive glycosylation sites, and a hydrophobic region close to the COOH terminus.
H Persson; H Jörnvall; J Zabielski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  77     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6349-53     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
GENBANK/J01917;  J01918;  J01919;  J01920;  J01921;  J01922;  J01923;  J01924;  J01925;  J01926;  J01927;  J01928;  J01929;  J01930;  J01931;  J01932;  J01933;  J01934;  J01935;  J01936;  J01937;  J01938;  J01939;  J01940;  J01941;  J01942;  J01943;  J01944;  J01945;  J01946
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MeSH Terms
Adenoviruses, Human / genetics*
Amino Acid Sequence
Base Sequence
DNA, Viral / genetics
Genes, Viral
Glycoproteins / genetics*
Protein Precursors / genetics*
RNA, Messenger / genetics*
RNA, Viral / genetics
Viral Proteins / genetics*
Reg. No./Substance:
0/DNA, Viral; 0/Glycoproteins; 0/Protein Precursors; 0/RNA, Messenger; 0/RNA, Viral; 0/Viral Proteins

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