Document Detail

Multiple lumbar roots neurotizations with the lower intercostal nerves. Preliminary clinical and electrophysiological results in a sheep model.
MedLine Citation:
PMID:  18561947     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Neurotization of lumbar roots with lower intercostal nerves is a potential way to treat neurological deficits after spinal cord injury. The anatomical feasibility of such neurotizations in humans has already been reported. We propose to assess axonal regrowth after intercostal to lumbar neurotization in a sheep model. MATERIALS AND METHODS: Ten sheep had a left T11-L2, T12-L3, and T13-L4 neurotization. In 5 sheep, a L1 level left hemisection of the spinal cord was performed. The sheep had clinical and electrophysiological monitoring with a 6 mon follow-up. RESULTS: A flaccid paralysis with clinical asymmetry of the left abdominal wall was noted three months after surgery. This asymmetry improved in all the cases at the 6 mon follow-up. Motor potentials were detected without difficulty for the 3 neurotized nerves (L2, L3, and L4) in 5 sheep. In another sheep, motor potentials of the L3 root remained undetected. Eight sheep had postoperative complications responsible for the animals' death in 5 cases. CONCLUSIONS: The current study demonstrates the technical feasibility of intercosto-lumbar neurotizations in a sheep model. We proved in all the animals--except in the case of 1 neurotized root--the ability of motor axon to regenerate through neurotization area down to the muscular effectors; however, we noted a high rate of postoperative complications in this animal model.
Raphaël Vialle; Pierre Lozeron; Maria-Carolina Loureiro; Marc Tadié
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-29
Journal Detail:
Title:  The Journal of surgical research     Volume:  149     ISSN:  1095-8673     ISO Abbreviation:  J. Surg. Res.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-15     Completed Date:  2008-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-205     Citation Subset:  IM    
Ecole de Chirurgie de l' Assistance Publique des Hôpitaux de Paris, Paris, France.
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MeSH Terms
Intercostal Nerves / transplantation*
Nerve Transfer / adverse effects,  methods*
Spinal Nerve Roots / surgery*

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