| Multiple lipid scoring system for prediction of coronary heart disease risk: application to African Americans. | |
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MedLine Citation:
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PMID: 17128681 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Clinicians often obtain a panel of lipids but then only use low-density-lipoprotein (LDL) cholesterol to make clinical decisions. We previously described the multiple lipid measure, a strategy that integrates information about seven lipid measures. Our current inquiry uses the multiple lipid measure to create a scoring system and validates that system in a second cohort. METHODS AND RESULTS: A scoring system that uses total cholesterol, high-density lipoprotein (HDL) cholesterol, LDL cholesterol and triglycerides was developed and tested. African-American participants of the Atherosclerosis Risk in Communities (ARIC) Study were used to validate the multiple lipid measure score. For nonsmokers, scores > or = 2 had a hazard ratio of 4.25 (95% CI 1.92-9.40) compared to reference scores of < or = -3 in adjusted survival analysis predicting incident coronary heart disease risk in the ARIC. The best conventional single lipid measure for nonsmokers was LDL cholesterol. Compared to LDL cholesterol <100 mg/dl, those with LDL cholesterol > or = 160 mg/dl had a hazard ratio of 2.31 (95% CI 1.13-4.75). For current smokers, the best conventional lipid measure was the total cholesterol/HDL cholesterol ratio, which was similar in predictive ability to the multiple lipid measure score. However, the multiple lipid measure score predicted an additional 10% of the cohort at risk compared to the total cholesterol/HDL cholesterol ratio. CONCLUSIONS: The use of the multiple lipid scoring system improves the assessment of incident coronary heart disease risk and may have utility for clinicians in integrating lipid values. |
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Authors:
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Charles J Everett; Arch G Mainous; Richelle J Koopman; Vanessa A Diaz |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the National Medical Association Volume: 98 ISSN: 0027-9684 ISO Abbreviation: J Natl Med Assoc Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-28 Completed Date: 2006-12-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503090 Medline TA: J Natl Med Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 1740-5 Citation Subset: IM |
Affiliation:
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Department of Family Medicine, Medical University of South Carolina, 295 Calhoun St., PO Box 250192, Charleston, SC 29425, USA. everettc@musc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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African Americans
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statistics & numerical data* Apolipoproteins B / blood Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Coronary Artery Disease / blood, ethnology Coronary Disease / blood*, epidemiology, ethnology* Health Status Indicators Humans Lipids / blood* Middle Aged Predictive Value of Tests Risk Assessment |
| Grant Support | |
ID/Acronym/Agency:
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2 D54 HP-00023//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins B; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 57-88-5/Cholesterol |
| Comments/Corrections | |
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