Document Detail

Multiple leukemic clones in acute leukemia of childhood.
MedLine Citation:
PMID:  273006     Owner:  NLM     Status:  MEDLINE    
Two abnormal karyotypes representing clonal populations have been demonstrated in three patients in the early stage of acute leukemia. The karyotypes were apparently unrelated in one patient, while in the other two, a relationship was conjectured. Both clones were present before therapy in two patients. Although a clone resistant to therapy was associated with relapse in one case, in two cases a clone has persisted in the lymphocyte culture during drug treatment with the patients in remission.
H G Morse; J M Ducore; T Hays; D Peakman; A Robinson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human genetics     Volume:  40     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-05-08     Completed Date:  1978-05-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  269-78     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Clone Cells
Leukemia / pathology*
Leukemia, Lymphoid / pathology
Leukemia, Myeloid / pathology
Lymphocytes / ultrastructure*
Remission, Spontaneous

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