Document Detail


Multiple infections and the evolution of virulence.
MedLine Citation:
PMID:  23347009     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Infections that consist of multiple parasite strains or species are common in the wild and are a major public health concern. Theory suggests that these infections have a key influence on the evolution of infectious diseases and, more specifically, on virulence evolution. However, we still lack an overall vision of the empirical support for these predictions. We argue that within-host interactions between parasites largely determine how virulence evolves and that experimental data support model predictions. Then, we explore the main limitation of the experimental study of such 'mixed infections', which is that it draws conclusions on evolutionary outcomes from studies conducted at the individual level. We also discuss differences between coinfections caused by different strains of the same species or by different species. Overall, we argue that it is possible to make sense out of the complexity inherent to multiple infections and that experimental evolution settings may provide the best opportunity to further our understanding of virulence evolution.
Authors:
Samuel Alizon; Jacobus C de Roode; Yannis Michalakis
Related Documents :
22925889 - Dissection of the plasmodium vivax reticulocyte binding-like proteins (pvrbps).
24041869 - Cytomegalovirus diseases after hematopoietic stem cell transplantation: a mini-review.
22440529 - Designing a protocol to reduce catheter-associated urinary tract infections among hospi...
22633509 - Neuroimaging in cmv congenital infected neonates: how and when.
23981329 - Biology and host response to cyprinid herpesvirus 3 infection in common carp.
22286699 - Nitric oxide nanoparticles: pre-clinical utility as a therapeutic for intramuscular abs...
9443219 - Influence of viral and bacterial respiratory infections on exacerbations and symptom se...
23433099 - Blastocystis infection in malaysia: evidence of waterborne and human-to-human transmiss...
3243369 - Pitted keratolysis: a manifestation of human dermatophilosis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Ecology letters     Volume:  -     ISSN:  1461-0248     ISO Abbreviation:  Ecol. Lett.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101121949     Medline TA:  Ecol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Blackwell Publishing Ltd/CNRS.
Affiliation:
Laboratoire MIVEGEC (UMR CNRS 5290, UR IRD 224, UM1, UM2), 911 Avenue Agropolis, B.P. 64501, 34394, Montpellier Cedex 5, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Relationship between changes in pulmonary V ? O 2 kinetics and autonomic regulation of blood flow.
Next Document:  A Comparison of Anthropometric and Training Characteristics between Recreational Female Marathoners ...