Document Detail

Multiple infections and the evolution of virulence.
MedLine Citation:
PMID:  23347009     Owner:  NLM     Status:  Publisher    
Infections that consist of multiple parasite strains or species are common in the wild and are a major public health concern. Theory suggests that these infections have a key influence on the evolution of infectious diseases and, more specifically, on virulence evolution. However, we still lack an overall vision of the empirical support for these predictions. We argue that within-host interactions between parasites largely determine how virulence evolves and that experimental data support model predictions. Then, we explore the main limitation of the experimental study of such 'mixed infections', which is that it draws conclusions on evolutionary outcomes from studies conducted at the individual level. We also discuss differences between coinfections caused by different strains of the same species or by different species. Overall, we argue that it is possible to make sense out of the complexity inherent to multiple infections and that experimental evolution settings may provide the best opportunity to further our understanding of virulence evolution.
Samuel Alizon; Jacobus C de Roode; Yannis Michalakis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Ecology letters     Volume:  -     ISSN:  1461-0248     ISO Abbreviation:  Ecol. Lett.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101121949     Medline TA:  Ecol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Blackwell Publishing Ltd/CNRS.
Laboratoire MIVEGEC (UMR CNRS 5290, UR IRD 224, UM1, UM2), 911 Avenue Agropolis, B.P. 64501, 34394, Montpellier Cedex 5, France.
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