Document Detail


Multiple functions of a glioblastoma fusion oncogene.
MedLine Citation:
PMID:  23298839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RNA sequencing facilitates the discovery of novel gene fusions in cancer. In this issue of the JCI, Parker et al. identify an FGFR3-TACC3 fusion oncogene in glioblastoma and demonstrate a novel mechanism of pathogenicity. A miR-99a binding site within the 3'-untranslated region (3'-UTR) of FGFR3 is lost, releasing FGFR3 signaling from miR-99a-dependent inhibition and greatly enhancing tumor progression relative to WT FGFR3. These results provide compelling insight into the pathogenicity of a novel fusion oncogene and suggest new therapeutic approaches for a subset of glioblastomas.
Authors:
Ivan Babic; Paul S Mischel
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Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-09
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-04-19     Completed Date:  2013-05-13     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  548-51     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Neoplasms / genetics*
Gene Fusion*
Glioblastoma / genetics*
Humans
Male
MicroRNAs / genetics*
Microtubule-Associated Proteins / genetics*
Receptor, Fibroblast Growth Factor, Type 3 / genetics*
Grant Support
ID/Acronym/Agency:
CA119347/CA/NCI NIH HHS; NS73831/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/MIRN99 microRNA, human; 0/MicroRNAs; 0/Microtubule-Associated Proteins; 0/TACC3 protein, human; EC 2.7.10.1/FGFR3 protein, human; EC 2.7.10.1/Receptor, Fibroblast Growth Factor, Type 3
Comments/Corrections
Comment On:
J Clin Invest. 2013 Feb 1;123(2):855-65   [PMID:  23298836 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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