| Multiple forms of uridine kinase in normal and neoplastic rat liver. | |
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MedLine Citation:
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PMID: 4331862 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two species of uridine kinase with molecular weights of approximately 120000 (I) and 30000 (II) have been identified in the rat liver system. Species I predominates in the 7-day postnatal and adult rat liver and increases in the regenerating remnant of the latter after partial hepatectomy; the concentration of species II is low in these tissues. Species I also predominates in the slow-growing hepatomas 5123D and 7800. In contrast, II is the predominant form in the foetal rat liver and accounts for 40% of the total activity in the rapidly growing Novikoff ascites hepatoma. In contrast to species II, which was stable, species I was inactivated by preincubation for 30min at 37 degrees C, before assay at 23 degrees C. |
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Authors:
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G Krystal; T E Webb |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Biochemical journal Volume: 124 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1971 Oct |
Date Detail:
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Created Date: 1972-03-04 Completed Date: 1972-03-04 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 943-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / enzymology* Chromatography Cytoplasm / enzymology Fetus Hepatectomy Hot Temperature Isoenzymes / analysis* Liver / enzymology* Liver Neoplasms / enzymology* Liver Regeneration Molecular Weight Neoplasms, Experimental / enzymology Phosphotransferases / analysis* Rats Uridine |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 58-96-8/Uridine; EC 2.7.-/Phosphotransferases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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