Document Detail

Multiple endocrine neoplasia type 1 is not rare in Japan.
MedLine Citation:
PMID:  9622300     Owner:  NLM     Status:  MEDLINE    
Multiple endocrine neoplasia type 1 (MEN 1) is rarely reported in Japanese and other oriental populations. To examine if there is a racial difference in the prevalence of MEN 1, we initiated extensive work on patients with endocrine tumors for additional lesions, and annual screening of family members of affected patients. In a four-year study, eleven asymptomatic patients were found by family screening, and the number of patients with MEN 1 in our clinics increased from 16 to 38. Estimated prevalence of MEN 1 was no less than 0.018/1000. MEN 1 may not be as rare as had been thought in Japanese, and the prevalence of MEN 1 in Japanese would not be significantly different from that of Caucasians. Systemic surveillance and extensive screening of family members are required for early detection and management of patients.
M Katai; A Sakurai; Y Itakura; Y Ikeo; K Nakajima; M Hara; S Iijima; T Kaneko; M Kobayashi; K Ichikawa; T Aizawa; K Hashizume
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrine journal     Volume:  44     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-08-07     Completed Date:  1998-08-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  841-5     Citation Subset:  IM    
Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine, Matsumoto, Japan.
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MeSH Terms
Asian Continental Ancestry Group / genetics*
Japan / epidemiology
Middle Aged
Multiple Endocrine Neoplasia Type 1 / epidemiology*,  genetics
Population Surveillance

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