Document Detail


Multiple endocrine neoplasia type 1 with upper gastrointestinal hemorrhage and perforation: a case report and review.
MedLine Citation:
PMID:  23482249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary syndrome known to predispose subjects to endocrine neoplasms in a variety of tissues such as the parathyroid glands, pituitary gland, pancreas and gastrointestinal tract. We herein report a patient with a past history of pituitary adenoma, presenting with symptoms of chronic diarrhea for nearly one year and a sudden upper gastrointestinal hemorrhage as well as perforation without signs. Nodules in the duodenum and in the uncinate process and tail of pancreas and enlargement of the parathyroid glands were detected on preoperative imaging. Gastroscopy revealed significant ulceration and esophageal reflux diseases. The patient underwent subtotal parathyroidectomy and autotransplantation, pylorus-preserving pancreaticoduodenectomy and pancreatic tail resection and recovered well. The results observed in our patient suggest that perforation and bleeding of intestine might be symptoms of Zollinger-Ellison Syndrome in patients with MEN1.
Authors:
Ying-Ying Lu; Feng Zhu; Da-Dao Jing; Xie-Ning Wu; Lun-Gen Lu; Gen-Quan Zhou; Xing-Peng Wang
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  19     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-03-13     Completed Date:  2013-12-06     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  1322-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy
Duodenal Diseases / diagnosis,  etiology*,  surgery
Gastrointestinal Hemorrhage / diagnosis,  etiology*,  surgery
Gastroscopy
Humans
Intestinal Perforation / diagnosis,  etiology*,  surgery
Magnetic Resonance Imaging
Male
Multiple Endocrine Neoplasia Type 1 / complications*,  diagnosis
Pancreatectomy
Pancreaticoduodenectomy
Parathyroidectomy
Predictive Value of Tests
Tomography, X-Ray Computed
Treatment Outcome
Zollinger-Ellison Syndrome / diagnosis,  etiology*,  surgery
Comments/Corrections

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