| Multiple endocrine neoplasia 2 (MEN 2)/MEN 2A (Sipple syndrome). | |
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MedLine Citation:
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PMID: 7712656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple endocrine neoplasia type 2A (MEN 2A, Sipple syndrome) is an autosomal dominant phakomatosis and is most likely a paracrinopathy. The cardinal manifestations of MEN 2A--medullary thyroid carcinoma, pheochromocytoma, and hyperparathyroidism--indicate that the condition is one of the inherited cancer syndromes. Cutaneous, lichen amyloidosis-like lesions place MEN 2A among the genodermatoses. The gene of MEN 2A, designated as MEN2A, is in the pericentromeric region of chromosome 10; this allows for reliable prenatal and presymptomatic DNA diagnosis. |
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Authors:
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B G Kousseff |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Dermatologic clinics Volume: 13 ISSN: 0733-8635 ISO Abbreviation: Dermatol Clin Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-05-12 Completed Date: 1995-05-12 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8300886 Medline TA: Dermatol Clin Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 91-7 Citation Subset: IM |
Affiliation:
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Division of Medical Genetics, University of South Florida, Tampa, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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genetics,
pathology Amyloidosis / genetics, pathology Carcinoma / genetics, pathology Chromosomes, Human, Pair 10 / genetics Humans Hyperparathyroidism / genetics, pathology Lichenoid Eruptions / genetics, pathology Multiple Endocrine Neoplasia Type 2a / genetics*, pathology Pheochromocytoma / genetics, pathology Skin Diseases / genetics, pathology Thyroid Neoplasms / genetics, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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