Document Detail

Multiple-electrode radiofrequency ablation: comparison with a conventional cluster electrode in an in vivo porcine kidney model.
MedLine Citation:
PMID:  17675619     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare multiple-electrode radiofrequency (RF) ablation versus RF ablation with a cluster electrode in an in vivo porcine kidney model.
MATERIALS AND METHODS: Thirteen female pigs (mean weight, 45 kg) were used for the study. In each animal, RF ablations were performed for 12 minutes with a conventional cluster electrode in one kidney (controls, n = 13) and a multiple-electrode configuration in the contralateral organ. Multiple-electrode ablations were performed with electrodes 1.5 cm apart (group 1, n = 7) or 2.0 cm apart (group 2, n = 6). The mean maximum temperature at the electrode tips was determined. After each animal was euthanized, the kidneys were removed and the ablation zones were sectioned into 5-mm transverse slices. A representative slice was stained with 2,3,5-triphenyl-2H-tetrazolium chloride. Standard ablation zone metrics were measured and differences between groups were analyzed for statistical significance.
RESULTS: The mean maximum ablation zone diameter was 3.0 cm +/- 0.6 (SD) for controls, compared with 5.0 cm +/- 0.5 for group 1 (P < .0001) and 4.4 cm +/- 1.0 for group 2 (P = .002). Mean ablation zone minimum diameter was higher for group 1 (P = .002) and group 2 (P = .03) than for controls. Isoperimetric ratios were lowest for group 2 (P = .04 vs controls) whereas the highest temperatures at the electrode tips were observed with group 1 (P = .02 vs controls).
CONCLUSION: In normal porcine kidney, multiple-electrode RF ablation produced larger zones of ablation than a cluster electrode. Efficacy was greater when electrodes were spaced 1.5 cm apart than when they were spaced 2.0 cm apart.
Paul F Laeseke; Lisa A Sampson; Tina M Frey; Rajat Mukherjee; Thomas C Winter; Fred T Lee; Chris L Brace
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of vascular and interventional radiology : JVIR     Volume:  18     ISSN:  1051-0443     ISO Abbreviation:  J Vasc Interv Radiol     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-06     Completed Date:  2008-04-04     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  9203369     Medline TA:  J Vasc Interv Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1005-10     Citation Subset:  IM    
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MeSH Terms
Catheter Ablation / instrumentation*,  methods
Electrodes, Implanted
Equipment Design
Kidney / surgery*
Linear Models
Models, Animal
Research Design
Sus scrofa

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