Document Detail


Multiple effector mechanisms induced by recombinant Listeria monocytogenes anticancer immunotherapeutics.
MedLine Citation:
PMID:  19203646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Listeria monocytogenes is a facultative intracellular gram-positive bacterium that naturally infects professional antigen presenting cells (APC) to target antigens to both class I and class II antigen processing pathways. This infection process results in the stimulation of strong innate and adaptive immune responses, which make it an ideal candidate for a vaccine vector to deliver heterologous antigens. This ability of L. monocytogenes has been exploited by several researchers over the past decade to specifically deliver tumor-associated antigens that are poorly immunogenic such as self-antigens. This review describes the preclinical studies that have elucidated the multiple immune responses elicited by this bacterium that direct its ability to influence tumor growth.
Authors:
Anu Wallecha; Kyla Driscoll Carroll; Paulo Cesar Maciag; Sandra Rivera; Vafa Shahabi; Yvonne Paterson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in applied microbiology     Volume:  66     ISSN:  0065-2164     ISO Abbreviation:  Adv. Appl. Microbiol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-02-10     Completed Date:  2009-03-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370413     Medline TA:  Adv Appl Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-27     Citation Subset:  IM    
Affiliation:
Department of Antibody Technology ImClone Systems, a wholly-owned subsidiary of Eli Lilly & Co. New York, NY 10014, USA.
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MeSH Terms
Descriptor/Qualifier:
Antigen-Presenting Cells / immunology
Cancer Vaccines / immunology,  therapeutic use*
Humans
Listeria Infections / immunology*,  microbiology
Listeria monocytogenes / genetics,  immunology*,  pathogenicity
Neoplasms / immunology,  therapy*
T-Lymphocytes, Regulatory / immunology
Vaccines, Synthetic / immunology,  therapeutic use*
Virulence
Virulence Factors / genetics,  immunology
Chemical
Reg. No./Substance:
0/Cancer Vaccines; 0/Vaccines, Synthetic; 0/Virulence Factors

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