Document Detail


Multiple developmental roles of Ahnak are suggested by localization to sites of placentation and neural plate fusion in the mouse conceptus.
MedLine Citation:
PMID:  14516657     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Ahnak is a gigantic (700 kD) phosphoprotein with a unique structure whose expression and cellular localization are dynamically regulated during cell cycle progression. Here, we report that Ahnak is localized to sites of major morphogenesis during mouse placentation and neurulation. Ahnak was found in: (i) derivatives of trophectoderm, including chorionic ectoderm prior to and during union with the ectoplacental cone, presumptive syncytiotrophoblast cells in the chorionic labyrinth, and giant cells at the trophoblast-uterine interface; (ii) the allantois prior to, during, and after union with the chorion; and (iii) the tips of the neural plate during formation of the neural tube. On the basis of these observations, we suggest that Ahnak may play heretofore unrecognized roles in tissue union during normal mouse development.
Authors:
Karen M Downs; Jacalyn McHugh; Andrew J Copp; Emma Shtivelman
Related Documents :
16996057 - Retinal and ciliary body pigment epithelium suppress activation of t lymphocytes via tr...
3917417 - Expression of a neurofilament protein by the precursors of a subpopulation of ventral s...
16158417 - Further characterization of embryonic stem cell-derived radial glial cells.
7386157 - Effects of isoproterenol on postnatal tooth development in mice with special reference ...
10463577 - Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with ...
9674997 - Developmental schedule of the postnatal rat testis determined by flow cytometry.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Mechanisms of development     Volume:  119 Suppl 1     ISSN:  0925-4773     ISO Abbreviation:  Mech. Dev.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-09-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9101218     Medline TA:  Mech Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  S31-8     Citation Subset:  IM    
Affiliation:
Department of Anatomy, University of Wisconsin-Madison Medical School, 1300 University Avenue, Madison, WI 53706, USA. kdowns@facstaff.wisc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
HD36847/HD/NICHD NIH HHS; HD42706/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gene expression pattern analysis of the tight junction protein, Claudin, in the early morphogenesis ...
Next Document:  Coordinated expression of Rb gene family in the mammary gland.