| Multiple cutaneous and uterine leiomyomatosis (Reed's syndrome). | |
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MedLine Citation:
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PMID: 16403393 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 51-year-old woman with a history of uterine fibroids status post myomectomy and hysterectomy presented for evaluation and treatment of intermittently painful papules of the left shoulder. Histopathologic examination showed a proliferation of smooth muscle fascicles consistent with the diagnosis of cutaneous leiomyomas. Genetic sequencing demonstrated a novel mutation in the fumarate hydratase gene that confirmed the diagnosis of Reed's syndrome. A subset of individuals with Reed's syndrome is predisposed to develop a papillary renal-cell carcinoma, so appropriate radiologic examinations should be performed. Treatment of the pain caused by cutaneous leiomyomas includes the use of nifedipine, nitroglycerine, phenoxybenzamine, surgical excision, and carbon dioxide laser ablation. |
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Authors:
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Gene Kim |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2005-12-30 |
Journal Detail:
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Title: Dermatology online journal Volume: 11 ISSN: 1087-2108 ISO Abbreviation: Dermatol. Online J. Publication Date: 2005 |
Date Detail:
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Created Date: 2006-01-11 Completed Date: 2006-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610776 Medline TA: Dermatol Online J Country: United States |
Other Details:
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Languages: eng Pagination: 21 Citation Subset: IM |
Affiliation:
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Department of Dermatology, New York University School of Medicine, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Fumarate Hydratase / genetics Humans Leiomyomatosis / diagnosis, genetics, pathology* Middle Aged Point Mutation Skin Neoplasms / diagnosis, genetics, pathology* Syndrome Uterine Neoplasms / diagnosis, genetics, pathology* |
| Chemical | |
Reg. No./Substance:
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EC 4.2.1.2/Fumarate Hydratase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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