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Multiple controls for the synthesis of muscle-specific proteins in BC3H1 cells.
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MedLine Citation:
PMID:  7061588     Owner:  NLM     Status:  MEDLINE    
The regulation of the synthesis of muscle-specific proteins has been examined in BC3H1 cells, a smooth muscle-like cell line isolated by Schubert et al. (J. Cell Biol., 1974, 61: 398-413.). The synthesis of both creatine kinase and the acetylcholine receptor appear to be under dual control, a positive control due to cell-cell contact which increases the rate of synthesis of this protein, and a negative signal, elicited by serum components, that decreases the rate of synthesis of these proteins. Induction of muscle-specific proteins in BC3H1 cells is a reversible process and can be arrested after partial induction has taken place by the addition of serum or high-molecular-weight protein fraction from serum to these cells. The high-molecular-weight protein fraction from serum is not by itself mitogenic for Bc3H1 cells and cannot be replaced by a variety of known hormones (mitogenic factors).
R Munson; K L Caldwell; L Glaser
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of cell biology     Volume:  92     ISSN:  0021-9525     ISO Abbreviation:  J. Cell Biol.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0375356     Medline TA:  J Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  350-6     Citation Subset:  IM; S    
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MeSH Terms
Cell Aggregation
Cell Differentiation / drug effects
Cells, Cultured
Creatine Kinase / biosynthesis*
Culture Media
DNA Replication / drug effects
Enzyme Induction
Growth Substances / blood
Muscle Proteins / biosynthesis*
Muscle, Smooth / physiology*
Receptors, Cholinergic / biosynthesis*
Grant Support
Reg. No./Substance:
0/Culture Media; 0/Growth Substances; 0/Muscle Proteins; 0/Receptors, Cholinergic; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Cell Biol
ISSN: 0021-9525
ISSN: 1540-8140
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 2 Year: 1982
Volume: 92 Issue: 2
First Page: 350 Last Page: 356
ID: 2112083
Publisher Id: 82142712
PubMed Id: 7061588

Multiple controls for the synthesis of muscle-specific proteins in BC3H1 cells

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