Document Detail

Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism?
MedLine Citation:
PMID:  14745921     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The characteristics of the phenotype of the malformed phenytoin-exposed infant can help to clarify the mechanism of the drug's teratogenesis. One postulated mechanism is vascular disruption. CASE: An infant who was exposed to phenytoin as monotherapy throughout pregnancy was born with the following abnormalities: midface hypoplasia, digit hypoplasia with syndactyly in the hands and feet, meningomyelocele, talipes equinovarus, and a long skin pedicle on the back. The mother was also exposed to cigarette smoking and alcohol during the pregnancy. CONCLUSIONS: The malformations of the hands and feet, and the talipes deformity are potential effects of vascular disruption, a postulated fetal effect of both phenytoin and cigarette smoking. The mechanism of the teratogenicity of phenytoin may have included episodes of bradyarrhythmia in the fetus; however, no such episodes were documented.
Helen M Lyon; Lewis B Holmes; Taosheng Huang
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  67     ISSN:  1542-0752     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-27     Completed Date:  2004-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  993-6     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Children's Hospital, Boston, Massachusetts, USA.
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MeSH Terms
Abnormalities, Drug-Induced*
Abnormalities, Multiple / etiology*,  physiopathology
Anoxia / etiology*,  physiopathology
Anticonvulsants / adverse effects*
Epilepsy / drug therapy
Gestational Age
Infant, Newborn
Ischemia / etiology*,  physiopathology
Maternal Exposure
Phenytoin / adverse effects*
Pregnancy Complications / drug therapy
Reg. No./Substance:
0/Anticonvulsants; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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