| Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism? | |
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MedLine Citation:
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PMID: 14745921 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The characteristics of the phenotype of the malformed phenytoin-exposed infant can help to clarify the mechanism of the drug's teratogenesis. One postulated mechanism is vascular disruption. CASE: An infant who was exposed to phenytoin as monotherapy throughout pregnancy was born with the following abnormalities: midface hypoplasia, digit hypoplasia with syndactyly in the hands and feet, meningomyelocele, talipes equinovarus, and a long skin pedicle on the back. The mother was also exposed to cigarette smoking and alcohol during the pregnancy. CONCLUSIONS: The malformations of the hands and feet, and the talipes deformity are potential effects of vascular disruption, a postulated fetal effect of both phenytoin and cigarette smoking. The mechanism of the teratogenicity of phenytoin may have included episodes of bradyarrhythmia in the fetus; however, no such episodes were documented. |
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Authors:
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Helen M Lyon; Lewis B Holmes; Taosheng Huang |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Birth defects research. Part A, Clinical and molecular teratology Volume: 67 ISSN: 1542-0752 ISO Abbreviation: Birth Defects Res. Part A Clin. Mol. Teratol. Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2004-01-27 Completed Date: 2004-07-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101155107 Medline TA: Birth Defects Res A Clin Mol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 993-6 Citation Subset: IM |
Copyright Information:
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Copyright 2003 Wiley-Liss, Inc. |
Affiliation:
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Children's Hospital, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced* Abnormalities, Multiple / etiology*, physiopathology Adult Anoxia / etiology*, physiopathology Anticonvulsants / adverse effects* Epilepsy / drug therapy Female Gestational Age Humans Infant, Newborn Ischemia / etiology*, physiopathology Maternal Exposure Phenytoin / adverse effects* Pregnancy Pregnancy Complications / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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