Document Detail

Multiple cerebral infarctions in a patient with Churg-Strauss syndrome.
MedLine Citation:
PMID:  20047058     Owner:  NLM     Status:  MEDLINE    
Neurological manifestation of Churg-Strauss syndrome (CSS) is common and usually consists of peripheral neuropathy due to small-vessel vasculitis, while cerebral manifestation is less frequent. We report the case of a 77-year-old woman with multiple cerebral infarctions and hypereosinophilia. The presence of hypereosinophilia, asthma, sinusitis and vasculitis led to the diagnosis of CSS. As cerebral infarctions occurred monophasically and an elevation of heart enzymes was present, we assumed cardiac involvement and multiple cerebral infarctions due to cardiac embolism. Treatment with high-dose IV methylprednisone and cyclophosphamide pulses led to significant improvement. This case illustrates multiple cerebral infarctions in CSS. CSS should always be considered in patients with hypereosinophilia and stroke.
Leyli Ghaeni; Eberhard Siebert; Florian Ostendorf; Matthias Endres; Uwe Reuter
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Publication Detail:
Type:  Letter     Date:  2010-01-03
Journal Detail:
Title:  Journal of neurology     Volume:  257     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-02     Completed Date:  2010-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  678-80     Citation Subset:  IM    
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MeSH Terms
Cerebral Infarction / etiology*
Churg-Strauss Syndrome / complications*
Diffusion Magnetic Resonance Imaging / methods

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