Document Detail

Multiple cases of Burkitt's lymphoma and other neoplasms in families in the North Mara District of Tanzania.
MedLine Citation:
PMID:  6937447     Owner:  NLM     Status:  MEDLINE    
In an area of Tanzania in which Burkitt's lymphoma (BL) is endemic, five families are described in which multiple cases of BL were found or BL occurred with other neoplasms. The patients include two brothers and one half-brother with BL, two brothers with BL, a woman with nasopharyngeal carcinoma (NPC) whose daughter had BL, a boy with BL whose sister developed chronic myelogenous leukaemia (CML), and a man with CML whose son developed BL. The two full-sib pairs with BL is significantly more than would be expected to have arisen by chance and the association of BL with NPC and CML among close relatives is remarkable in view of the rarity of the last two neoplasms in the study area. It is suggested that genetic factors may be important. It is suggested that genetic factors may be important in determining susceptibility to the three malignancies in this population, but the possibility that the clustering of cases within families may be due to local environmental factors cannot be excluded.
G Brubaker; A G Levin; C M Steel; G Creasey; H M Cameron; C A Linsell; P G Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  26     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1981-05-21     Completed Date:  1981-05-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  165-70     Citation Subset:  IM    
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MeSH Terms
Burkitt Lymphoma / epidemiology,  genetics*
Child, Preschool
Chromosomes, Human, 21-22 and Y
Leukemia, Myeloid / epidemiology,  genetics*
Nasopharyngeal Neoplasms / epidemiology,  genetics*
Neoplasms, Multiple Primary / epidemiology,  genetics*
Grant Support

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