Document Detail


Multiple antioxidants and L-arginine modulate inflammation and dyslipidemia in chronic renal failure rats.
MedLine Citation:
PMID:  20199183     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The kidney is an important source of L-arginine, the endogenous precursor of nitric oxide (NO). Surgical problems requiring extensive renal mass reduction (RMR) decrease renal NO production, leading to multiple hemodynamic and homeostatic disorders manifested by hypertension, oxidative stress, and increased inflammatory cytokines. Using the RMR model of chronic renal failure (CRF), we assessed the effects of twelve weeks' administration of L-arginine and/or a mixture of antioxidants (L-carnitine, catechin, vitamins E and C) on plasma cytokines, soluble intercellular adhesion molecule-1 (sICAM-1), nitrate and nitrites (NO(2)/NO(3)), lipid profile, blood pressure, and renal function. CRF rats showed increased plasma IL-1 alpha, IL1-beta, IL-6, TNF-alpha, and sICAM-1 levels and decreased anti-inflammatory cytokines IL-4 and 10 levels, hypertension, and dyslipidemia. L-arginine treatment improved kidney functions, decreased systolic blood pressure, and decreased inflammatory cytokines levels. Antioxidants administration decreased inflammatory cytokines and sICAM-1 levels and increased IL-4 levels. Combined use of both L-arginine and the antioxidant mixture were very effective in their tendency to recover normal values of kidney functions, plasma cytokines, sICAM-1, blood pressure, NO(2)/NO(3), cholesterol, and triglycerides concentrations. Indeed, the effects of L-arginine and the antioxidants on the reduction of proinflammatory cytokines may open new perspectives in the treatment of uremia.
Authors:
Aida A Korish
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Renal failure     Volume:  32     ISSN:  1525-6049     ISO Abbreviation:  Ren Fail     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-03-04     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  England    
Other Details:
Languages:  eng     Pagination:  203-13     Citation Subset:  IM    
Affiliation:
Department of Physiology, Faculty of Medicine, King Saud University, Saudi Arabia. iaidakorish@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Antioxidants / pharmacology*
Arginine / pharmacology*
Cytokines / blood
Dyslipidemias / drug therapy*,  physiopathology*
Enzyme-Linked Immunosorbent Assay
Inflammation / drug therapy,  physiopathology
Inflammation Mediators / metabolism
Intercellular Adhesion Molecule-1 / blood
Kidney Failure, Chronic / drug therapy*,  physiopathology*
Kidney Function Tests
Male
Nitric Oxide / metabolism
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Cytokines; 0/Inflammation Mediators; 10102-43-9/Nitric Oxide; 126547-89-5/Intercellular Adhesion Molecule-1; 74-79-3/Arginine

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