Document Detail

Multiple anomalies in a fetus exposed to low-dose methotrexate in the first trimester.
MedLine Citation:
PMID:  12039119     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Methotrexate has multiple therapeutic uses in women of reproductive age including treatment for ectopic pregnancy, neoplastic disease, autoimmune disorders, and inflammatory conditions. More frequent use of methotrexate may result in an increased number of exposures in pregnant women and their fetuses. CASE: A 16-year-old gravida 1, para 0 used oral methotrexate treatment of 7.5 mg per day for psoriasis for 2 days at 3.5 weeks postconception. Multiple anomalies were noted on an 18-week ultrasound. Fetopsy revealed craniofacial, axial skeletal, cardiopulmonary, and gastrointestinal abnormalities. CONCLUSION: A minimal, low-dose, brief exposure to methotrexate in the first trimester resulted in a fetus with multiple internal and external malformations. Some of the anomalies (craniofacial and skeletal) have been previously reported with first- trimester methotrexate exposure. This case depicts the association of cardiopulmonary and gastrointestinal abnormalities with methotrexate exposure.
Christine Nguyen; Adam J Duhl; Cathleen S Escallon; Karin J Blakemore
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  99     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-31     Completed Date:  2002-09-03     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  599-602     Citation Subset:  AIM; IM    
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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MeSH Terms
Abnormalities, Multiple / chemically induced*,  ultrasonography
Bone and Bones / abnormalities
Craniofacial Abnormalities / chemically induced,  ultrasonography
Depression / complications,  drug therapy*
Digestive System / ultrasonography
Digestive System Abnormalities
Fetal Death / chemically induced*
Heart Defects, Congenital / chemically induced,  ultrasonography
Infant, Newborn
Methotrexate / administration & dosage,  adverse effects*
Pregnancy Complications / drug therapy*
Pregnancy Trimester, First
Psoriasis / complications,  drug therapy*
Sertraline / therapeutic use
Ultrasonography, Prenatal
Reg. No./Substance:
59-05-2/Methotrexate; 79617-96-2/Sertraline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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