| Multiple actions of high-density lipoprotein. | |
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MedLine Citation:
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PMID: 18520722 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: The most accepted property of high-density lipoprotein is reverse cholesterol transport. However, other beneficial actions may contribute to the antiatherogenic role of high-density lipoprotein. This review addresses the action of high-density lipoprotein beyond reverse cholesterol transport. RECENT FINDINGS: High-density lipoprotein cholesterol levels are inversely associated with coronary heart disease and other forms of vascular disease. Apart from transferring excess cholesterol to the liver, high-density lipoprotein exhibits favorable effects on oxidation, inflammation, thrombosis and endothelial function. Some of these actions are at least in part attributed to high-density lipoprotein-associated enzymes, such as paraoxonase and platelet-activating factor acetylhydrolase. However, high-density lipoprotein can become dysfunctional and proatherogenic under certain circumstances. SUMMARY: Current data suggest that high-density lipoprotein possesses various properties beyond reverse cholesterol transport. However, many issues on the exact role of high-density lipoprotein remain unknown. Future research is needed. |
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Authors:
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Matilda Florentin; Evangelos N Liberopoulos; Anthony S Wierzbicki; Dimitri P Mikhailidis |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in cardiology Volume: 23 ISSN: 1531-7080 ISO Abbreviation: Curr. Opin. Cardiol. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-03 Completed Date: 2008-08-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608087 Medline TA: Curr Opin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 370-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents
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metabolism Anti-Inflammatory Agents / metabolism Antioxidants / metabolism Atherosclerosis / metabolism* Endothelium, Vascular / metabolism Fibrinolytic Agents / metabolism Humans Kidney / metabolism Lipoproteins, HDL / chemistry, metabolism* Molecular Structure |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Anti-Inflammatory Agents; 0/Antioxidants; 0/Fibrinolytic Agents; 0/Lipoproteins, HDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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