| Multiple acquisitions with global inversion cycling (MAGIC): a multislice technique for vascular-space-occupancy dependent fMRI. | |
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MedLine Citation:
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PMID: 14705039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, a new fMRI technique, termed vascular-space-occupancy (VASO), was introduced that uses T1-based blood nulling to detect cerebral blood volume (CBV) changes during brain activity. However, similar to other T1-preparation methods, this technique is hampered by the fact that there is only one zero-crossing on the relaxation curve, presently limiting its application to single-slice studies. A multislice VASO-fMRI method is presented that employs a series of nonselective 180 degrees pulses to periodically invert the magnetization and maintain it around zero, while acquiring slices in between. The effects of magnetization transfer and signal contamination by stimulated echoes are discussed. Solutions to reduce the effect of T1-signal decay as a function of slice number are provided. Phantom data show excellent agreement between experiments and numerical simulations. Multislice VASO-fMRI images of visual stimulation show effective blood nulling in all slices and appropriate functional activations in all volunteers (n=4). |
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Authors:
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Hanzhang Lu; Peter C M van Zijl; Jeroen Hendrikse; Xavier Golay |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 51 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-01-05 Completed Date: 2004-05-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 9-15 Citation Subset: IM |
Copyright Information:
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Copyright 2003 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Volume* Brain Mapping Cerebrovascular Circulation* Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods* Phantoms, Imaging Photic Stimulation |
| Grant Support | |
ID/Acronym/Agency:
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P41-RR15241/RR/NCRR NIH HHS; R01-NS37664/NS/NINDS NIH HHS; R21-EB000991/EB/NIBIB NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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