Document Detail


Multiple unrelated chromosomal abnormalities in host cells after cord blood transplantation.
MedLine Citation:
PMID:  20418786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We experienced a 16-year-old patient with T-cell acute lymphoblastic leukemia, who had multiple unrelated chromosomal abnormalities in host cells after chemotherapy and cord blood transplantation (CBT). In 7 consecutive cytogenetic studies after CBT, he showed various chromosomal abnormalities including t(1;11)(p32;q23), t(8;21)(q22.2;q22.2), t(6;10)(p21.3;q26), and del(7) (q22q34). His chromosomal abnormalities were unstable and different in each cytogenetic study except del(7)(q22q34). He had neither anemia nor leukopenia, and his thrombocytopenia continuously improved after CBT. He was clinically stable for 2.5 years despite his complex chromosomal abnormalities. The clinical relevance of genetic instabilities in host cells after CBT is unclear, and long-term monitoring with additional cases is needed.
Authors:
HeeWon Moon; JinHee Cho; Mina Hur; Yeo-Min Yun; Sung-Hee Han; Mark Hong Lee
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  32     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-05-27     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  332-5     Citation Subset:  IM    
Affiliation:
Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Chromosome Aberrations*
Cord Blood Stem Cell Transplantation*
Humans
Male
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*,  therapy*
Remission Induction

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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