Document Detail

Multiple EGFR ligands participate in guiding migrating border cells.
MedLine Citation:
PMID:  16712835     Owner:  NLM     Status:  MEDLINE    
Cell migration is an important feature of embryonic development as well as tumor metastasis. Border cells in the Drosophila ovary have emerged as a useful in vivo model for uncovering the molecular mechanisms that control many aspects of cell migration including guidance. It was previously shown that two receptor tyrosine kinases, epidermal growth factor receptor (EGFR) and PDGF- and VEGF-related receptor (PVR), together contribute to border cell migration. Whereas the ligand for PVR, PVF1, is known to guide border cells, it is unclear which of the four activating EGFR ligands function in this process. We developed an assay to detect the ability of secreted factors to reroute migrating border cells in vivo and tested the activity of EGFR ligands compared to PVF1. Two ligands, Keren and Spitz, guided border cells whereas the other ligands, Gurken and Vein, did not. In addition, only Keren and Spitz were expressed at the appropriate stage in the oocyte, the target of border cell migration. Therefore, a complex combination of EGFR and PVR ligands together guide border cells to the oocyte.
Jocelyn A McDonald; Elaine M Pinheiro; Lisa Kadlec; Trudi Schupbach; Denise J Montell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-04-21
Journal Detail:
Title:  Developmental biology     Volume:  296     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-21     Completed Date:  2006-09-19     Revised Date:  2012-06-01    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  94-103     Citation Subset:  IM    
Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA.
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MeSH Terms
Cell Movement / physiology*
Drosophila Proteins / agonists,  metabolism,  physiology*
Drosophila melanogaster / cytology,  physiology*
Egg Proteins / metabolism,  physiology
Epidermal Growth Factor / physiology
Membrane Proteins / physiology
Neuregulins / physiology
Ovary / cytology,  physiology*
Protein Kinases / physiology*
Receptor, Epidermal Growth Factor / agonists,  physiology*
Receptors, Invertebrate Peptide / agonists,  physiology*
Transforming Growth Factor alpha / physiology
Grant Support
Reg. No./Substance:
0/Drosophila Proteins; 0/Egg Proteins; 0/Ligands; 0/Membrane Proteins; 0/Neuregulins; 0/Pvf1 protein, Drosophila; 0/Receptors, Invertebrate Peptide; 0/Transforming Growth Factor alpha; 0/gurken protein, Drosophila; 0/keren protein, Drosophila; 148175-53-5/spi protein, Drosophila; 182299-68-9/vein protein, Drosophila; 62229-50-9/Epidermal Growth Factor; EC 2.7.-/Protein Kinases; EC protein, Drosophila; EC, Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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