Document Detail

Multiple dosing of ephedra-free dietary supplements: hemodynamic, electrocardiographic, and bacterial contamination effects.
MedLine Citation:
PMID:  23361101     Owner:  NLM     Status:  MEDLINE    
Four popular ephedra-free dietary supplements were evaluated for their effects on heart rate (HR), blood pressure (BP), and electrocardiographic (ECG) parameters. Twelve healthy men participated in a study randomized for product sequence, with a 21-day washout period between supplement-administration phases. Throughout the study, Holter monitors were used to assess ECG and HR activity. BP was assessed automatically on multiple occasions. The supplements were ingested three times daily for 3 days. Caffeine content, microbial load, and serum caffeine concentrations were determined. Mean systolic (SBP) and diastolic BP (DBP) readings showed significant increases relative to baseline (10.8 ± 2.5 and 5.3 ± 3.1 mm Hg, respectively; P < 0.05). All supplements significantly increased HR and decreased bradycardia runs; abnormal atrial/ventricular events were frequently noted. Gastrointestinal and sympathomimetic symptoms were also common. Two supplements were heavily contaminated with Bacillus species. In light of these findings, the use of ephedra-free dietary supplements should be discouraged in individuals with hypertension, diabetes, or other cardiovascular diseases.
L Foster; M C Allan; A Khan; P Moore; D K Williams; M Hubbard; L Dixon; B J Gurley
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-12-11
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  93     ISSN:  1532-6535     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-19     Completed Date:  2013-04-09     Revised Date:  2013-04-26    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-74     Citation Subset:  AIM; IM    
Department of Dietetics and Nutrition, College of Health Professions University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
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MeSH Terms
Bacillus / isolation & purification*
Blood Pressure / drug effects*
Caffeine / blood
Cross-Over Studies
Dietary Supplements* / microbiology
Drug Contamination*
Electrocardiography / drug effects*
Heart Rate / drug effects*
Theophylline / blood
Reg. No./Substance:
58-08-2/Caffeine; 58-55-9/Theophylline; Q3565Y41V7/1,7-dimethylxanthine
Comment In:
Clin Pharmacol Ther. 2013 Apr;93(4):297-9   [PMID:  23511783 ]

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