| Multiple dosing of ephedra-free dietary supplements: hemodynamic, electrocardiographic, and bacterial contamination effects. | |
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MedLine Citation:
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PMID: 23361101 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four popular ephedra-free dietary supplements were evaluated for their effects on heart rate (HR), blood pressure (BP), and electrocardiographic (ECG) parameters. Twelve healthy men participated in a study randomized for product sequence, with a 21-day washout period between supplement-administration phases. Throughout the study, Holter monitors were used to assess ECG and HR activity. BP was assessed automatically on multiple occasions. The supplements were ingested three times daily for 3 days. Caffeine content, microbial load, and serum caffeine concentrations were determined. Mean systolic (SBP) and diastolic BP (DBP) readings showed significant increases relative to baseline (10.8 ± 2.5 and 5.3 ± 3.1 mm Hg, respectively; P < 0.05). All supplements significantly increased HR and decreased bradycardia runs; abnormal atrial/ventricular events were frequently noted. Gastrointestinal and sympathomimetic symptoms were also common. Two supplements were heavily contaminated with Bacillus species. In light of these findings, the use of ephedra-free dietary supplements should be discouraged in individuals with hypertension, diabetes, or other cardiovascular diseases. |
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Authors:
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L Foster; M C Allan; A Khan; P Moore; D K Williams; M Hubbard; L Dixon; B J Gurley |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2012-12-11 |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 93 ISSN: 1532-6535 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-19 Completed Date: 2013-04-09 Revised Date: 2013-04-26 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 267-74 Citation Subset: AIM; IM |
Affiliation:
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Department of Dietetics and Nutrition, College of Health Professions University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bacillus / isolation & purification* Blood Pressure / drug effects* Caffeine / blood Cross-Over Studies Dietary Supplements* / microbiology Drug Contamination* Electrocardiography / drug effects* Heart Rate / drug effects* Humans Male Theophylline / blood |
| Chemical | |
Reg. No./Substance:
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58-08-2/Caffeine; 58-55-9/Theophylline; Q3565Y41V7/1,7-dimethylxanthine |
| Comments/Corrections | |
Comment In:
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Clin Pharmacol Ther. 2013 Apr;93(4):297-9
[PMID:
23511783
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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