Document Detail

Multiple Associated Variants Increase the Heritability Explained for Plasma Lipids and Coronary Artery Disease.
MedLine Citation:
PMID:  25170055     Owner:  NLM     Status:  Publisher    
BACKGROUND: -Plasma lipid levels as well as coronary artery disease (CAD) have been shown to be highly heritable with estimates ranging from 40%-60%. However, top variants detected by large-scale genome-wide association studies (GWAS) explain only a fraction of the total variance in plasma lipid phenotypes and CAD.
METHODS AND RESULTS: -We performed a conditional and joint association analysis using summary-level statistics from two large GWAS meta-analyses: (1) the Global Lipids Genetics Consortium (GLGC) study, and (2) the Coronary ARtery DIsease Genome-wide Replication and Meta-analysis (CARDIoGRAM) study. There were 100,184 individuals from 46 GLGC studies for plasma lipids, and 22,233 cases and 64,762 controls from 14 studies for CAD. We detected a number of loci where multiple independent SNPs were associated with lipid traits within a locus (12 out of 33 loci for high-density lipoprotein cholesterol [HDL-C], 10 of 35 loci for low-density lipoprotein cholesterol [LDL-C], 13 of 44 loci for total cholesterol [TC], and 8 of 28 loci for triglycerides [TG]), reaching genome-wide significance (P<5×10(-8)), nearly doubling the heritability explained by GWAS (3.6% to 7.6% for HDL-C, 5.0% to 8.8% for LDL-C, 5.5% to 8.8% for TC, and 5.7% to 8.5% for TG). Multiple SNPs were also associated with CAD (3 of 15 loci, 9.6% to 11.4% of increased heritability).
CONCLUSIONS: -These results demonstrate that a portion of the missing heritability for lipid traits and CAD can be explained by multiple variants at each locus.
Hayato Tada; Hong-Hee Won; Olle Melander; Jian Yang; Gina M Peloso; Sekar Kathiresan
Related Documents :
14601725 - Growth, livability, and feed conversion of 1957 versus 2001 broilers when fed represent...
8559725 - Mitigating the effects of halofuginone on skin strength by feeding l-proline to broiler...
1784565 - Effect of fructooligosaccharide on salmonella colonization of the chicken intestine.
842625 - Daily rhythms of lipogenesis in fat and lean white-throated sparrows zonotrichia albico...
14574625 - Cholesterol and tau protein--findings in alzheimer's and niemann pick c's disease.
15023395 - Effect of genistein supplementation on tissue genistein and lipid peroxidation of serum...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-28
Journal Detail:
Title:  Circulation. Cardiovascular genetics     Volume:  -     ISSN:  1942-3268     ISO Abbreviation:  Circ Cardiovasc Genet     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101489144     Medline TA:  Circ Cardiovasc Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nurse-led orthopaedic clinic in total joint replacement.
Next Document:  Usefulness of C-Reactive Protein as a Disease Activity Marker in Crohn Disease according to the Loca...