Document Detail

Multiple-ASSR thresholds in infants and young children with hearing loss.
MedLine Citation:
PMID:  21034700     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The multiple auditory steady-state response (multiple ASSR) is a promising technique for determining thresholds for infants and children. However, there are few data for infants and young children with hearing loss where multiple-ASSR thresholds have been compared to frequency-specific gold standard (i.e., behavioral or tone-evoked auditory brainstem response [tone ABR]) measures.
PURPOSE: The study compared multiple-ASSR and tone-ABR thresholds and assessed how well "normal" ASSR levels differentiate normal from elevated thresholds.
RESEARCH DESIGN: Multiple-ASSR and tone-ABR results (to air-conduction stimuli) were obtained in infants and young children with hearing loss or normal hearing.
STUDY SAMPLE: 98 infants with hearing loss (53 infants provided thresholds) and 34 infants with normal hearing.
DATA COLLECTION AND ANALYSIS: Multiple-ASSR and tone-ABR results were typically completed on the same day. Correlations between ASSR and ABR thresholds, linear regressions, and ASSR-minus-ABR threshold difference scores were calculated for each group (normal or hearing loss), and for both groups combined.
RESULTS: Multiple-ASSR thresholds (dB HL) were strongly correlated (r = .97) with tone-ABR thresholds (dB nHL) for 500, 1000, 2000, and 4000 Hz. Mean (±1 SD) difference scores (ASSR-minus-ABR) were 10.7 ± 9.0, 9.5 ± 9.4, 9.2 ± 9.0, and 6.3 ± 9.5 dB for 500, 1000, 2000, and 4000 Hz, respectively. The previously published "normal" ASSR levels accurately differentiated normal from elevated thresholds. Out of 523 tests with elevated tone-ABR thresholds, the multiple ASSR was "normal" in only 22 tests. In these 13 infants, other ASSR frequencies were elevated, and thus the infants would not have "passed" the ASSR.
CONCLUSIONS: There are few studies of infants and young children comparing ASSR thresholds to frequency-specific gold standard measures, especially using the multiple-ASSR technique. The present study, comparing multiple-ASSR to tone-ABR thresholds, nearly doubles the multiple-ASSR sample size in the literature. The results indicate that the multiple-ASSR and tone-ABR thresholds are strongly correlated, and the "normal" multiple-ASSR levels of 50, 45, 40, and 40 dB HL correctly classified children as having "normal" or "elevated" thresholds. However, due to the lack of air- and bone-conduction data in infants with different types and degrees of hearing loss, further ASSR research is needed.
Anna Van Maanen; David R Stapells
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Academy of Audiology     Volume:  21     ISSN:  1050-0545     ISO Abbreviation:  J Am Acad Audiol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114646     Medline TA:  J Am Acad Audiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  535-45     Citation Subset:  IM    
Copyright Information:
American Academy of Audiology.
School of Audiology and Speech Sciences, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Acoustic Stimulation
Audiometry, Evoked Response*
Auditory Threshold / physiology*
Brain Stem / physiopathology
Child, Preschool
Evoked Potentials, Auditory, Brain Stem / physiology*
Hearing Loss, Sensorineural / diagnosis*,  physiopathology
Middle Aged
Patient Satisfaction
Pitch Perception / physiology
Reference Values
Sound Spectrography
Grant Support
MOP67103//Canadian Institutes of Health Research

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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