Document Detail


Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin.
MedLine Citation:
PMID:  25109877     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue" disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies.
Authors:
Katherine A Hoadley; Christina Yau; Denise M Wolf; Andrew D Cherniack; David Tamborero; Sam Ng; Max D M Leiserson; Beifang Niu; Michael D McLellan; Vladislav Uzunangelov; Jiashan Zhang; Cyriac Kandoth; Rehan Akbani; Hui Shen; Larsson Omberg; Andy Chu; Adam A Margolin; Laura J Van't Veer; Nuria Lopez-Bigas; Peter W Laird; Benjamin J Raphael; Li Ding; A Gordon Robertson; Lauren A Byers; Gordon B Mills; John N Weinstein; Carter Van Waes; Zhong Chen; Eric A Collisson; ; Christopher C Benz; Charles M Perou; Joshua M Stuart
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2014-08-07
Journal Detail:
Title:  Cell     Volume:  158     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-08-16     Completed Date:  -     Revised Date:  2014-12-05    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  929-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
K08 CA137153/CA/NCI NIH HHS; K08 CA137153/CA/NCI NIH HHS; K08 CA176561/CA/NCI NIH HHS; P01 CA099031/CA/NCI NIH HHS; P30 CA016086/CA/NCI NIH HHS; P30 CA016672/CA/NCI NIH HHS; P30 CA016672/CA/NCI NIH HHS; P50 CA083639/CA/NCI NIH HHS; P50 CA083639/CA/NCI NIH HHS; P50 CA098258/CA/NCI NIH HHS; R01 CA071468/CA/NCI NIH HHS; R01 CA071468/CA/NCI NIH HHS; R01 CA180006/CA/NCI NIH HHS; R01 CA180778/CA/NCI NIH HHS; R01 HG005690/HG/NHGRI NIH HHS; R01 HG005690/HG/NHGRI NIH HHS; R01 HG007069/HG/NHGRI NIH HHS; R01 HG007069/HG/NHGRI NIH HHS; R01CA180006/CA/NCI NIH HHS; R21 CA155679/CA/NCI NIH HHS; R21 CA155679/CA/NCI NIH HHS; R21 CA176561/CA/NCI NIH HHS; U01 CA168394/CA/NCI NIH HHS; U01 CA168394/CA/NCI NIH HHS; U24 CA143799/CA/NCI NIH HHS; U24 CA143799/CA/NCI NIH HHS; U24 CA143835/CA/NCI NIH HHS; U24 CA143840/CA/NCI NIH HHS; U24 CA143840/CA/NCI NIH HHS; U24 CA143843/CA/NCI NIH HHS; U24 CA143843/CA/NCI NIH HHS; U24 CA143845/CA/NCI NIH HHS; U24 CA143845/CA/NCI NIH HHS; U24 CA143848/CA/NCI NIH HHS; U24 CA143848/CA/NCI NIH HHS; U24 CA14385/CA/NCI NIH HHS; U24 CA143858/CA/NCI NIH HHS; U24 CA143858/CA/NCI NIH HHS; U24 CA143866/CA/NCI NIH HHS; U24 CA143866/CA/NCI NIH HHS; U24 CA143867/CA/NCI NIH HHS; U24 CA143867/CA/NCI NIH HHS; U24 CA143867-05/CA/NCI NIH HHS; U24 CA143882/CA/NCI NIH HHS; U24 CA143882/CA/NCI NIH HHS; U24 CA143883/CA/NCI NIH HHS; U24 CA143883/CA/NCI NIH HHS; U24 CA144025/CA/NCI NIH HHS; U54 CA112970/CA/NCI NIH HHS; U54 CA112970/CA/NCI NIH HHS; U54 HG003067/HG/NHGRI NIH HHS; U54 HG003067/HG/NHGRI NIH HHS; U54 HG003079/HG/NHGRI NIH HHS; U54 HG003079/HG/NHGRI NIH HHS; U54 HG003273/HG/NHGRI NIH HHS; U54 HG003273/HG/NHGRI NIH HHS; ZIA-DC-000073/DC/NIDCD NIH HHS; ZIA-DC-000074/DC/NIDCD NIH HHS
Investigator
Investigator/Affiliation:
Rachel Abbott / ; Scott Abbott / ; B Arman Aksoy / ; Kenneth Aldape / ; Adrian Ally / ; Samirkumar Amin / ; Dimitris Anastassiou / ; J Todd Auman / ; Keith A Baggerly / ; Miruna Balasundaram / ; Saianand Balu / ; Stephen B Baylin / ; Stephen C Benz / ; Benjamin P Berman / ; Brady Bernard / ; Ami S Bhatt / ; Inanc Birol / ; Aaron D Black / ; Tom Bodenheimer / ; Moiz S Bootwalla / ; Jay Bowen / ; Ryan Bressler / ; Christopher A Bristow / ; Angela N Brooks / ; Bradley Broom / ; Elizabeth Buda / ; Robert Burton / ; Yaron S N Butterfield / ; Daniel Carlin / ; Scott L Carter / ; Tod D Casasent / ; Kyle Chang / ; Stephen Chanock / ; Lynda Chin / ; Dong-Yeon Cho / ; Juok Cho / ; Eric Chuah / ; Hye-Jung E Chun / ; Kristian Cibulskis / ; Giovanni Cirello / ; James Cleland / ; Melissa Cline / ; Brian Craft / ; Chad J Creighton / ; Ludmila Danilova / ; Tanja Davidsen / ; Caleb Davis / ; Nathan D Dees / ; Kim Delenhaunty / ; John A Demchok / ; Noreen Dhalla / ; Daniel DiCara / ; Huyen Dinh / ; Jason R Dobson / ; Deepti Dodda / ; HarshaVardhan Doddapaneni / ; Lawrence Donehower / ; David J Dooling / ; Gideon Dresdner / ; Jennifer Drummond / ; Andrea Eakin / ; Mary Edgerton / ; Jim M Elred / ; Greg Eley / ; Kyle Ellrott / ; Cheng Fan / ; Suzanne Fei / ; Ina Felau / ; Scott Frazer / ; Samuel S Freeman / ; Jessica Frick / ; Catrina C Fronick / ; Lucinda L Fullerton / ; Robert Fulton / ; Stacey B Gabriel / ; Jianjiong Gao / ; Julie M Gastier-Foster / ; Nils Gehlenborg / ; Myra George / ; Gad Getz / ; Richard Gibbs / ; Mary Goldman / ; Abel Gonzalez-Perez / ; Benjamin Gross / ; Ranabir Guin / ; Preethi Gunaratne / ; Angela Hadjipanayis / ; Mark P Hamilton / ; Stanley R Hamilton / ; Leng Han / ; Yi Han / ; Hollie A Harper / ; Psalm Haseley / ; David Haussler / ; D Neal Hayes / ; David I Heiman / ; Elena Helman / ; Carmen Helsel / ; Shelley M Herbrich / ; James G Herman / ; Toshinori Hinoue / ; Carrie Hirst / ; Martin Hirst / ; Robert A Holt / ; Alan P Hoyle / ; Lisa Iype / ; Anders Jacobsen / ; Stuart R Jeffreys / ; Mark A Jensen / ; Corbin D Jones / ; Steven J M Jones / ; Zhenlin Ju / ; Joonil Jung / ; Andre Kahles / ; Ari Kahn / ; Joelle Kalicki-Veizer / ; Divya Kalra / ; Krishna-Latha Kanchi / ; David W Kane / ; Hoon Kim / ; Jaegil Kim / ; Theo Knijenburg / ; Daniel C Koboldt / ; Christie Kovar / ; Roger Kramer / ; Richard Kreisberg / ; Raju Kucherlapati / ; Marc Ladanyi / ; Eric S Lander / ; David E Larson / ; Michael S Lawrence / ; Darlene Lee / ; Eunjung Lee / ; Semin Lee / ; William Lee / ; Kjong-Van Lehmann / ; Kalle Leinonen / ; Kristen M Leraas / ; Seth Lerner / ; Douglas A Levine / ; Lora Lewis / ; Timothy J Ley / ; Haiyan I Li / ; Jun Li / ; Wei Li / ; Han Liang / ; Tara M Lichtenberg / ; Jake Lin / ; Ling Lin / ; Pei Lin / ; Wenbin Liu / ; Yingchun Liu / ; Yuexin Liu / ; Philip L Lorenzi / ; Charles Lu / ; Yilling Lu / ; Lovelace J Luquette / ; Singer Ma / ; Vincent J Magrini / ; Harshad S Mahadeshwar / ; Elaine R Mardis / ; Adam Margolin / ; Marco A Marra / ; Michael Mayo / ; Cynthia McAllister / ; Sean E McGuire / ; Joshua F McMichael / ; James Melott / ; Shaowu Meng / ; Matthew Meyerson / ; Piotr A Mieczkowski / ; Christopher A Miller / ; Martin L Miller / ; Michael Miller / ; Richard A Moore / ; Margaret Morgan / ; Donna Morton / ; Lisle E Mose / ; Andrew J Mungall / ; Donna Muzny / ; Lam Nguyen / ; Michael S Noble / ; Houtan Noushmehr / ; Michelle O'Laughlin / ; Akinyemi I Ojesina / ; Tai-Hsien Ou Yang / ; Brad Ozenberger / ; Angeliki Pantazi / ; Michael Parfenov / ; Peter J Park / ; Joel S Parker / ; Evan Paull / ; Chandra Sekhar Pedamallu / ; Todd Pinhl / ; Craig Pohl / ; David Pot / ; Alexei Protopopov / ; Teresa Przytycka / ; Amie Radenbaugh / ; Nilsa C Ramirez / ; Ricardo Ramirez / ; Gunnar Rätsch / ; Jeffrey Reid / ; Xiao-jia Ren / ; Boris Reva / ; Sheila M Reynolds / ; Suhn K Rhie / ; Jeffrey Roach / ; Hector Rovira / ; Michael Ryan / ; Gordon Saksena / ; Sofie Salama / ; Chris Sander / ; Netty Santoso / ; Jacqueline E Schein / ; Heather Schmidt / ; Nikolaus Schultz / ; Steven E Schumacher / ; Jonathan Seidman / ; Yasin Senbabaoglu / ; Sahil Seth / ; Samantha Sharpe / ; Ronglai Shen / ; Margi Sheth / ; Yan Shi / ; Ilya Shmulevich / ; Grace O Silva / ; Janae V Simons / ; Rileen Sinha / ; Payal Sipahimalani / ; Scott M Smith / ; Heidi J Sofia / ; Artem Sokolov / ; Mathew G Soloway / ; Xingzhi Song / ; Carrie Sougnez / ; Paul Spellman / ; Louis Staudt / ; Chip Stewart / ; Petar Stojanov / ; Xiaoping Su / ; S Onur Sumer / ; Yichao Sun / ; Teresa Swatloski / ; Barbara Tabak / ; Angela Tam / ; Donghui Tan / ; Jiabin Tang / ; Roy Tarnuzzer / ; Barry S Taylor / ; Nina Thiessen / ; Vesteinn Thorsson / ; Timothy Triche / ; David J Van Den Berg / ; Fabio Vandin / ; Richard J Varhol / ; Charles J Vaske / ; Umadevi Veluvolu / ; Roeland Verhaak / ; Doug Voet / ; Jason Walker / ; John W Wallis / ; Peter Waltman / ; Yunhu Wan / ; Min Wang / ; Wenyl Wang / ; Zhining Wang / ; Scot Waring / ; Nils Weinhold / ; Daniel J Weisenberger / ; Michael C Wendl / ; David Wheeler / ; Matthew D Wilkerson / ; Richard K Wilson / ; Lisa Wise / ; Andrew Wong / ; Chang-Jiun Wu / ; Chia-Chin Wu / ; Hsin-Ta Wu / ; Junyuan Wu / ; Todd Wylie / ; Liu Xi / ; Ruibin Xi / ; Zheng Xia / ; Andrew W Xu / ; Da Yang / ; Liming Yang / ; Lixing Yang / ; Yang Yang / ; Jun Yao / ; Rong Yao / ; Kai Ye / ; Kosuke Yoshihara / ; Yuan Yuan / ; Alfred K Yung / ; Travis Zack / ; Dong Zeng / ; Jean Claude Zenklusen / ; Hailei Zhang / ; Jianhua Zhang / ; Nianxiang Zhang / ; Qunyuan Zhang / ; Wei Zhang / ; Siyuan Zheng / ; Jing Zhu / ; Erik Zmuda / ; Lihua Zou /

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