Document Detail


Multipin technology in the preparation and screening of peptide libraries.
MedLine Citation:
PMID:  7509657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peptide libraries are relatively new sources of enormous numbers of unique compounds, fodder for the mill of drug discovery programs. Their enormous diversity derives from vast numbers of combinations of a small number of monomers (Geysen et al., 1986). For example, a complete hexapeptide library synthesized from just 10 monomers (amino acids) has one million unique compounds in it. In principle, other types of combinatorial libraries can have equally vast numbers of members; for example, the monomers can be N-acyl glycines, giving rise to the so-called "peptoids" (Simon et al., 1992); or the monomers could be monosaccharides or nucleotides.
Authors:
S J Rodda; T J Mason; N J Maeji
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australasian biotechnology     Volume:  3     ISSN:  1036-7128     ISO Abbreviation:  Australas Biotechnol     Publication Date:    1993 Nov-Dec
Date Detail:
Created Date:  1994-04-07     Completed Date:  1994-04-07     Revised Date:  2002-12-13    
Medline Journal Info:
Nlm Unique ID:  9113681     Medline TA:  Australas Biotechnol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  346-7     Citation Subset:  B    
Affiliation:
Chiron Mimotopes Pty Ltd., St., Clayton, Victoria.
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MeSH Terms
Descriptor/Qualifier:
Biotechnology / methods*
Epitopes / chemistry
Peptides / chemical synthesis*,  chemistry,  immunology
Peptoids
Chemical
Reg. No./Substance:
0/Epitopes; 0/Peptides; 0/Peptoids

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