| Multipin technology in the preparation and screening of peptide libraries. | |
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MedLine Citation:
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PMID: 7509657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peptide libraries are relatively new sources of enormous numbers of unique compounds, fodder for the mill of drug discovery programs. Their enormous diversity derives from vast numbers of combinations of a small number of monomers (Geysen et al., 1986). For example, a complete hexapeptide library synthesized from just 10 monomers (amino acids) has one million unique compounds in it. In principle, other types of combinatorial libraries can have equally vast numbers of members; for example, the monomers can be N-acyl glycines, giving rise to the so-called "peptoids" (Simon et al., 1992); or the monomers could be monosaccharides or nucleotides. |
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Authors:
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S J Rodda; T J Mason; N J Maeji |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Australasian biotechnology Volume: 3 ISSN: 1036-7128 ISO Abbreviation: Australas Biotechnol Publication Date: 1993 Nov-Dec |
Date Detail:
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Created Date: 1994-04-07 Completed Date: 1994-04-07 Revised Date: 2002-12-13 |
Medline Journal Info:
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Nlm Unique ID: 9113681 Medline TA: Australas Biotechnol Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 346-7 Citation Subset: B |
Affiliation:
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Chiron Mimotopes Pty Ltd., St., Clayton, Victoria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biotechnology
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methods* Epitopes / chemistry Peptides / chemical synthesis*, chemistry, immunology Peptoids |
| Chemical | |
Reg. No./Substance:
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0/Epitopes; 0/Peptides; 0/Peptoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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