| Multiphase pseudocontinuous arterial spin labeling (MP-PCASL) for robust quantification of cerebral blood flow. | |
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MedLine Citation:
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PMID: 20578056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pseudocontinuous arterial spin labeling (PCASL) has been demonstrated to provide the sensitivity of the continuous arterial spin labeling method while overcoming many of the limitations of that method. Because the specification of the phases in the radiofrequency pulse train in PCASL defines the tag and control conditions of the flowing arterial blood, its tagging efficiency is sensitive to factors, such as off-resonance fields, that induce phase mismatches between the radiofrequency pulses and the flowing spins. As a result, the quantitative estimation of cerebral blood flow with PCASL can exhibit a significant amount of error when these factors are not taken into account. In this paper, the sources of the tagging efficiency loss are characterized and a novel PCASL method that utilizes multiple phase offsets is proposed to reduce the tagging efficiency loss in PCASL. Simulations are performed to evaluate the feasibility and the performance of the proposed method. Quantitative estimates of cerebral blood flow obtained with multiple phase offset PCASL are compared to estimates obtained with conventional PCASL and pulsed arterial spin labeling. Our results show that multiple phase offset PCASL provides robust cerebral blood flow quantification while retaining much of the sensitivity advantage of PCASL. |
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Authors:
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Youngkyoo Jung; Eric C Wong; Thomas T Liu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 64 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 799-810 Citation Subset: IM |
Copyright Information:
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2010 Wiley-Liss, Inc. |
Affiliation:
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Center for Functional MRI and Department of Radiology, University of California San Diego, La Jolla, California 92093, USA. y2jung@ucsd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Brain / blood supply, physiology* Cerebral Arteries / physiology* Cerebrovascular Circulation / physiology* Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Magnetic Resonance Angiography / methods* Reproducibility of Results Sensitivity and Specificity Spin Labels |
| Grant Support | |
ID/Acronym/Agency:
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R01 EB002096/EB/NIBIB NIH HHS; R01 MH084796/MH/NIMH NIH HHS; R01 NS051661/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Spin Labels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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