| Multiparameter flow cytometry reveals myelodysplasia-related aberrant antigen expression in myelodysplastic/myeloproliferative neoplasms. | |
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MedLine Citation:
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PMID: 23283847 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Within the myelodysplastic/myeloproliferative neoplasm (MDS/MPN) category of the WHO (2008), only chronic myelomonocytic leukemia was so far evaluated by multiparameter flow cytometry (MFC). METHODS: To investigate the potential of MFC for MDS/MPNs, unclassifiable (MDS/MPNu), and refractory anemia associated with ring sideroblasts and marked thrombocytosis (RARS-T), we studied 91 patients with these entities (60 males/31 females; 35.3-87.4 years) for MDS-related aberrant immunophenotypes (≥2 different cell lineages with ≥3 aberrantly expressed antigens). Data were correlated with cytomorphology and cytogenetics. RESULTS: MFC identified MDS-related immunophenotypes in 54/91 (59.3%) of patients. Patients with or without MDS-related immunophenotype did not differ significantly by demographic characteristics, blood values, or median overall survival. MDS-related immunophenotype cases showed a higher number of aberrantly expressed antigens (mean ± SD, 4.9 ± 2.4 vs. 2.0 ± 1.4; P < 0.001). Aberrant karyotypes showed a similar frequency in patients with and without MDS-related immunophenotype (11/54; 20.4% vs. 7/37; 18.9%; P = n.s.). CONCLUSIONS: MDS-related immunophenotype are present in more than half of patients with MDS/MPNu and RARS-T. MFC therefore may be helpful to separate cases into more "MDS-like" or "MPN-like" subgroups. © 2012 International Clinical Cytometry Society. |
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Authors:
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Wolfgang Kern; Ulrike Bacher; Susanne Schnittger; Tamara Alpermann; Claudia Haferlach; Torsten Haferlach |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-2 |
Journal Detail:
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Title: Cytometry. Part B, Clinical cytometry Volume: - ISSN: 1552-4957 ISO Abbreviation: Cytometry B Clin Cytom Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101235690 Medline TA: Cytometry B Clin Cytom Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 International Clinical Cytometry Society. |
Affiliation:
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MLL Munich Leukemia Laboratory, Munich, Germany. wolfgang.kern@mll.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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