Document Detail

Multimodality topical therapy for refractory chronic rhinosinusitis: Our experience in thirteen patients with and twelve patients without nasal polyposis.
MedLine Citation:
PMID:  23398898     Owner:  NLM     Status:  Publisher    
The management of refractory chronic rhinosinusitis with and without nasal polyps is a challenge, as this entity is associated with a high rate of disease recurrence. This prospective controlled clinical study compared multimodality topical therapy to oral therapy in refractory chronic rhinosinusitis with and without nasal polyps. The primary outcome measures consisted of Lund-Kennedy symptoms and endoscopic appearance scores, and the secondary outcome measures included hematoxylin and eosin histology of the treated mucosa, before and after therapy. The impact of topical therapy was more favorable and more sustained than oral therapy, especially in the refractory chronic rhinosinusitis with nasal polyps group. While topical therapy is not a panacea, it can, because of its safety profile, be repeated and/or sustained over extended periods hence avoiding the risks of prolonged oral corticosteroids, IV antibiotics and/or repeat surgery. © 2013 Blackwell Publishing Ltd.
Shikani Alan H; Kourelis Konstantinos; Alqudah Mohanned A; Shikani Scm Henry J; Cope Emily; Kirk Natalie; Bergstedt Diane; Basaraba Dvm Randall J; Leid Jeff G
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-7
Journal Detail:
Title:  Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery     Volume:  -     ISSN:  1749-4486     ISO Abbreviation:  Clin Otolaryngol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247023     Medline TA:  Clin Otolaryngol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Blackwell Publishing Ltd.
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore; Department of Otolaryngology-Head and Neck Surgery, Union Memorial Hospital, Baltimore.
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