Document Detail


Multimodality imaging of myocardial injury and remodeling.
MedLine Citation:
PMID:  20395347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Advances in cardiovascular molecular imaging have come at a rapid pace over the last several years. Multiple approaches have been taken to better understand the structural, molecular, and cellular events that underlie the progression from myocardial injury to myocardial infarction (MI) and, ultimately, to congestive heart failure. Multimodality molecular imaging including SPECT, PET, cardiac MRI, and optical approaches is offering new insights into the pathophysiology of MI and left ventricular remodeling in small-animal models. Targets that are being probed include, among others, angiotensin receptors, matrix metalloproteinases, integrins, apoptosis, macrophages, and sympathetic innervation. It is only a matter of time before these advances are applied in the clinical setting to improve post-MI prognostication and identify appropriate therapies in patients to prevent the onset of congestive heart failure.
Authors:
Christopher M Kramer; Albert J Sinusas; David E Sosnovik; Brent A French; Frank M Bengel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-04-15
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  51 Suppl 1     ISSN:  1535-5667     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-11     Completed Date:  2010-06-03     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107S-121S     Citation Subset:  IM    
Affiliation:
Departments of Medicine and Radiology, University of Virginia Health System, 1215 Lee St., Box 800170, Charlottesville, VA 22908, USA. ckramer@virginia.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Heart Failure / pathology
Humans
Macrophages / metabolism
Magnetic Resonance Imaging / methods*
Myocardial Infarction / pathology*
Myocardium / pathology*
Positron-Emission Tomography / methods*
Receptor, Angiotensin, Type 1 / chemistry
Spectrometry, Fluorescence / methods
Sympathetic Nervous System / pathology
Tomography, Emission-Computed, Single-Photon / methods*
Tomography, X-Ray Computed / methods
Ventricular Remodeling*
Grant Support
ID/Acronym/Agency:
K08 HL079984/HL/NHLBI NIH HHS; R01 HL058582/HL/NHLBI NIH HHS; R01 HL065662/HL/NHLBI NIH HHS; R01 HL078650/HL/NHLBI NIH HHS; R01 HL093038/HL/NHLBI NIH HHS; R01 HL093038-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Receptor, Angiotensin, Type 1
Comments/Corrections

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