Document Detail

Multimodal treatment of advanced adult Wilms tumor.
MedLine Citation:
PMID:  6278165     Owner:  NLM     Status:  MEDLINE    
We report 2 cases of advanced adult Wilms tumor that were treated with surgery, radiation and chemotherapy. The first patient had relapse of a Wilms tumor in the liver 2 years after nephrectomy. Combination chemotherapy, consisting of actinomycin D and vincristine, radiation therapy and final resection of the liver metastasis were successful and the patient has been free of disease for 4 years. The second patient had undergone transcatheter embolization of the renal artery elsewhere with the tentative diagnosis of an inoperable renal cell carcinoma metastatic to both lungs. A left renal tumor, weighing 4,500 gm., and a tumor thrombus in the vena cava extending to the right atrium were removed, and histologically diagnosed as a Wilms tumor. Subsequent chemotherapy and radiotherapy resulted in complete disappearance of the lung metastases. We conclude that multimodal treatment, namely a well timed combination of surgery, chemotherapy and radiotherapy, could potentially eradicate the disease even at an advanced stage.
M Hagiwara; M Tachibana; S Jitsukawa; M Murai; M Nakazono; M Hata; H Tazaki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  127     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  535-8     Citation Subset:  AIM; IM    
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MeSH Terms
Dactinomycin / therapeutic use
Drug Therapy, Combination
Embolization, Therapeutic
Kidney Neoplasms / therapy*
Liver Neoplasms / secondary
Lung Neoplasms / secondary
Neoplasm Recurrence, Local
Radiotherapy Dosage
Vincristine / therapeutic use
Wilms Tumor / secondary,  therapy*
Reg. No./Substance:
50-76-0/Dactinomycin; 57-22-7/Vincristine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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