Document Detail

Multimodal therapy for chronic tinnitus.
MedLine Citation:
PMID:  18616089     Owner:  NLM     Status:  MEDLINE    
From 2001 to 2006, we performed a retrospective study of patients suffering from chronic unilateral or bilateral tinnitus that was previously ineffectively treated by oral drugs [betahistine (Betaserc), extract of Ginkgo biloba (EGb 761), tanakan (Tebokan), and cinnarizine-dimenhydrinate (Arlevert), singly or in combination]. We divided 150 tinnitus patients (80 men, 70 women) into seven treatment groups. Treatments consisted of application of intravenous pentoxifylline, lidocaine, or vinpocetine (Cavinton) and combination of these agents with physiotherapy and soft laser. Mean duration (+/- standard deviation) of tinnitus in these patients was 7.4 +/- 6.0 years; their mean age was 55.6 +/- 12.5 years. The aim of our study was to compare treatment modalities and define their effectiveness for tinnitus relief. The most effective treatment was defined as a combination of Cavinton and physiotherapy. We evaluated pure lidocaine infusion therapy as ineffective. None of the treatment modalities had an objective correlate of improvement, though improvement was reported by a visual analog scale.
Ales Hahn; Lenka Radkova; Gabriela Achiemere; Vladislav Klement; Dario Alpini; Jaroslav Strouhal
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The international tinnitus journal     Volume:  14     ISSN:  0946-5448     ISO Abbreviation:  Int Tinnitus J     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-11     Completed Date:  2008-08-18     Revised Date:  2010-07-09    
Medline Journal Info:
Nlm Unique ID:  9612993     Medline TA:  Int Tinnitus J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-72     Citation Subset:  IM    
Ear, Nose, and Throat Department, Third Medical Faculty, Charles University, Prague, Czech Republic.
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MeSH Terms
Betahistine / therapeutic use
Chronic Disease
Cinnarizine / therapeutic use
Combined Modality Therapy
Dimenhydrinate / therapeutic use
Drug Combinations
Drug Therapy, Combination
Laser Therapy, Low-Level
Lidocaine / therapeutic use
Middle Aged
Pentoxifylline / therapeutic use
Physical Therapy Modalities
Plant Extracts / therapeutic use
Retrospective Studies
Tinnitus / rehabilitation*
Vinca Alkaloids / therapeutic use
Reg. No./Substance:
0/Drug Combinations; 0/Ginkgo biloba extract 761; 0/Plant Extracts; 0/Vinca Alkaloids; 0/cinnarizine, dimenhydrinate drug combination; 137-58-6/Lidocaine; 298-57-7/Cinnarizine; 42971-12-0/vinpocetine; 523-87-5/Dimenhydrinate; 5638-76-6/Betahistine; 6493-05-6/Pentoxifylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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