Document Detail

Multimodal tests of cerebrovascular reactivity in migraine: a transcranial Doppler study.
MedLine Citation:
PMID:  1512610     Owner:  NLM     Status:  MEDLINE    
Altered cerebral vasoreactivity (CVR) has been implicated in migraine. To test this hypothesis, we studied CVR as measured by transcranial Doppler ultrasound (TCD) in 11 migraineurs and 12 healthy controls of similar age. Mean flow velocities (MFV) in the middle cerebral artery (MCA) were recorded during a cognitive and two motor tasks. MFV in the posterior cerebral artery (PCA) were measured during photic stimulation and observation of complex images. The increase of MFV in the MCA during the cognitive task was greater in migraineurs than in controls (9.1% vs 5.0%; P = 0.06). The increase of MFV in both tests for PCA reactivity was significantly greater in migraineurs than in controls: 17.4% vs 9.9% for photic stimulation (P less than 0.05) and 20.3% vs 10.2% for observation of complex images (P less than 0.05). Owing to overlap of individual results, the discriminative value of both tests was unsatisfactory. The variability of flow velocities as measured by standard deviations of MFV was significantly greater in migraineurs than in controls during all tests of PCA vasoreactivity. Differences in CVR between migraineurs and normal controls may be detected by TCD testing, in particular in the PCA territory. For individual diagnostic purposes, CVR tests proved to be insufficient.
A Thie; M Carvajal-Lizano; U Schlichting; K Spitzer; K Kunze
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology     Volume:  239     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-09-28     Completed Date:  1992-09-28     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  338-42     Citation Subset:  IM    
Neurologische Universitätsklinik Eppendorf, Hamburg, Federal Republic of Germany.
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MeSH Terms
Blood Flow Velocity
Cerebral Arteries / ultrasonography*
Migraine Disorders / ultrasonography*
Pilot Projects
Reference Values

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