| Multimodal silica-shelled quantum dots: direct intracellular delivery, photosensitization, toxic, and microcirculation effects. | |
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MedLine Citation:
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PMID: 18494515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, we describe a multimodal QD probe with combined fluorescent and paramagnetic properties, based on silica-shelled single QD micelles with incorporated paramagnetic substances [tris(2,2,6,6-tetramethyl-3,5-heptanedionate)/gadolinium] into the micelle and/or silica coat. The probe was characterized with high photoluminescence quantum yield and good positive MRI contrast, low cytotoxicity, and easy intracellular delivery in viable cells. The intravenous administration of the probe in experimental animals did not affect significantly the physiological parameters and microcirculation (e.g., heart rate, blood pressure, diameter and shape of blood vessels), which makes it appropriate for tracing of blood circulation and in vivo multimodal imaging using fluorescent confocal microscopy, two-photon microscopy, and MRI. |
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Authors:
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Rumiana Bakalova; Zhivko Zhelev; Ichio Aoki; Kazuto Masamoto; Milka Mileva; Takayuki Obata; Makoto Higuchi; Veselina Gadjeva; Iwao Kanno |
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Publication Detail:
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Type: Journal Article Date: 2008-05-22 |
Journal Detail:
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Title: Bioconjugate chemistry Volume: 19 ISSN: 1520-4812 ISO Abbreviation: Bioconjug. Chem. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-19 Completed Date: 2008-07-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010319 Medline TA: Bioconjug Chem Country: United States |
Other Details:
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Languages: eng Pagination: 1135-42 Citation Subset: IM |
Affiliation:
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Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Chiba 263-8555, Japan. bakalova@nirs.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / diagnostic use, metabolism, toxicity Blood Pressure / drug effects Brain / blood supply*, drug effects* Contrast Media / metabolism, toxicity Fluorescent Dyes / diagnostic use, metabolism, toxicity Gadolinium / chemistry Heart Rate / drug effects Hela Cells Humans Intracellular Space / metabolism* Magnetics* Micelles Microcirculation / drug effects Photosensitizing Agents / diagnostic use*, metabolism*, toxicity Quantum Dots* Rats Silicon Dioxide / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Contrast Media; 0/Fluorescent Dyes; 0/Micelles; 0/Photosensitizing Agents; 7440-54-2/Gadolinium; 7631-86-9/Silicon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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