Document Detail


Multimodal optical imaging of microvessel network convective oxygen transport dynamics.
MedLine Citation:
PMID:  19340108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Convective oxygen transport by microvessels depends on several parameters, including red blood cell flux and oxygen saturation. We demonstrate the use of intravital microscopy techniques to measure hemoglobin saturations, red blood cell fluxes and velocities, and microvessel cross-sectional areas in regions of microvascular networks containing multiple vessels. With these methods, data can be obtained at high spatial and temporal resolution and correlations between oxygen transport and hemodynamic parameters can be assessed. In vivo data are presented for a mouse mammary adenocarcinoma grown in a dorsal skinfold window chamber model.
Authors:
Casey Dedeugd; Mamta Wankhede; Brian S Sorg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied optics     Volume:  48     ISSN:  1539-4522     ISO Abbreviation:  Appl Opt     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-02     Completed Date:  2009-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0247660     Medline TA:  Appl Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  D187-97     Citation Subset:  IM    
Affiliation:
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / blood supply*
Anatomy, Cross-Sectional
Animals
Biological Transport
Blood Flow Velocity
Erythrocytes*
Female
Mammary Neoplasms, Experimental / blood supply*
Mice
Mice, Nude
Microcirculation*
Microscopy / methods*
Microscopy, Confocal
Microvessels / pathology*
Oxygen / blood*
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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