Document Detail

Multimodal imaging in the elastase-induced aneurysm model in rabbits: a comparative study using serial DSA, MRA and CTA.
MedLine Citation:
PMID:  15088186     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: The elastase-induced aneurysm model in rabbits has proved to be suitable for testing new endovascular occlusion devices. The purpose of this study was to evaluate different imaging modalities for the depiction of anatomy and size of elastase-induced aneurysms and for serial follow-up imaging. MATERIALS AND METHODS: Elastase-induced aneurysms were created in eight Chinchilla bastard rabbits by endoluminal incubation of porcine elastase. Serial imaging was performed using intravenous DSA (IVDSA), contrast-enhanced MRA (CEMRA), and time-of-flight MRA (TOF) 14 days, 4 weeks and 3 months after aneurysm creation. Intraarterial DSA (IADSA) and CT angiography (CTA) were performed after 3 months. Aneurysm size and geometry (height H, width W, neck width N) were compared. RESULTS: On IVDSA after two weeks mean aneurysm height was 6.2 mm (range 2.8 - 11.0 mm), mean aneurysm width was 2.8 mm (range 2.0 - 4.2 mm) and mean aneurysm neck width was 2.7 mm (range 2.0 - 4.2 mm). We did not observed any statistically significant change in aneurysm dimensions during follow-up at 4 weeks (CEMRA: H: 5.4, W: 2.4, N: 2.4; TOF: H: 5.7, W: 2.4, N: 2.7) and 3 months (CEMRA: H: 5.8, W: 2.6, N: 2.6; TOF: H: 6.9, W: 2.8, N: 3.0). Aneurysm dimensions could be best seen on IADSA (H: 6.2, W: 3.0, N: 2.7) with good correlation to CTA (r = 0.94; H: 6.1, W: 2.8, N: 2.6), CE-MRA (r = 0.92), and TOF (r = 0.97). TOF was superior to CEMRA in delineating the aneurysm wall. CONCLUSIONS: Serial imaging using MRA, CTA or intravenous and intraarterial angiography is feasible in the elastase-induced aneurysm model. Contrast-enhanced MRA, TOF-MRA and CTA showed good correlation to IADSA and are all suitable for non-invasive pretherapeutic measurement of aneurysm size.
A Doerfler; W Becker; I Wanke; S Goericke; N Oezkan; M Forsting
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin     Volume:  176     ISSN:  1438-9029     ISO Abbreviation:  Rofo     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-16     Completed Date:  2004-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7507497     Medline TA:  Rofo     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  590-6     Citation Subset:  IM    
Department of Neuroradiology, Institute of Diagnostic and Interventional Radiology, University of Essen Medical School, Essen, Germany.
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MeSH Terms
Angiography, Digital Subtraction*
Contrast Media
Disease Models, Animal
Follow-Up Studies
Gadolinium DTPA / diagnostic use
Intracranial Aneurysm / chemically induced,  diagnosis*,  radiography*
Magnetic Resonance Angiography*
Pancreatic Elastase
Time Factors
Tomography, X-Ray Computed*
Reg. No./Substance:
0/Contrast Media; 80529-93-7/Gadolinium DTPA; EC Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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