Document Detail


Multimodal imaging of human cerebellum - merging X-ray phase microtomography, magnetic resonance microscopy and histology.
MedLine Citation:
PMID:  23145319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Imaging modalities including magnetic resonance imaging and X-ray computed tomography are established methods in daily clinical diagnosis of human brain. Clinical equipment does not provide sufficient spatial resolution to obtain morphological information on the cellular level, essential for applying minimally or non-invasive surgical interventions. Therefore, generic data with lateral sub-micrometer resolution have been generated from histological slices post mortem. Sub-cellular spatial resolution, lost in the third dimension as a result of sectioning, is obtained using magnetic resonance microscopy and micro computed tomography. We demonstrate that for human cerebellum grating-based X-ray phase tomography shows complementary contrast to magnetic resonance microscopy and histology. In this study, the contrast-to-noise values of magnetic resonance microscopy and phase tomography were comparable whereas the spatial resolution in phase tomography is an order of magnitude better. The registered data with their complementary information permit the distinct segmentation of tissues within the human cerebellum.
Authors:
Georg Schulz; Conny Waschkies; Franz Pfeiffer; Irene Zanette; Timm Weitkamp; Christian David; Bert Müller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-09
Journal Detail:
Title:  Scientific reports     Volume:  2     ISSN:  2045-2322     ISO Abbreviation:  Sci Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-12     Completed Date:  2013-05-23     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101563288     Medline TA:  Sci Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  826     Citation Subset:  IM    
Affiliation:
Biomaterials Science Center, University of Basel, Basel, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Cerebellum / radiography*
Diagnostic Imaging / methods*
Humans
Magnetic Resonance Imaging*
Microscopy
Synchrotrons
X-Ray Microtomography*
Comments/Corrections

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