Document Detail

Multilayer coating of gold nanoparticles with drug-polymer coadsorbates.
MedLine Citation:
PMID:  20964349     Owner:  NLM     Status:  In-Process    
The aim of our present study was the development of a drug multilayer-based carrier system for delivery of water-insoluble drugs. As drug, we applied the anticancer drug 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin, mTHPP, which is a model photosensitizer for photodynamic therapy. Gold nanoparticles (AuNP) with a diameter of 14.5 ± 0.9 nm were prepared and used as template for the layer-by-layer approach. The drug and the negatively charged polyelectrolyte (PE) poly(styrene sulfonate) sodium salt (PSS) were complexed with a new developed method using freeze-drying. The complexation efficiency was determined to be ∼11-12 monomers PSS per mTHPP molecule by CHNS analysis and UV/vis measurement. Molecular docking simulations revealed π-π interactions and H-bonding to be the responsible mechanisms. A drug multilayer system based on the layer-by-layer (LbL) technique utilized the water-soluble complex as anionic layer material and poly(allylamine hydrochloride) (PAH) as cationic layer. The modified AuNP were characterized by different physicochemical techniques such as UV/vis, ζ-potential, ICP-OES, and TEM. To the best of our knowledge, we could demonstrate for the first time the adsorption of three drug layers to a nanoparticulate system. Furthermore, the adaptation of the LbL-technique resulted in drastically increased drug deposition efficiency (factor of 100). Furthermore, we developed a new and comfortable way to solubilize water-insoluble drugs in water.
Nico Reum; Claudia Fink-Straube; Tobias Klein; Rolf W Hartmann; Claus-Michael Lehr; Marc Schneider
Related Documents :
10340219 - Sustained release chitosan microspheres prepared by novel spray drying methods.
18554679 - Acoustically active perfluorocarbon nanoemulsions as drug delivery carriers for camptot...
20497099 - Development and evaluation of novel polymeric nanoparticles of brimonidine tartrate.
20600269 - Alginate microsphere filled with carbon nanotube as drug carrier.
10425369 - Preparation of nanoparticles consisted of poly(l-lactide)-poly(ethylene glycol)-poly(l-...
9685869 - Body distribution of azidothymidine bound to hexyl-cyanoacrylate nanoparticles after i....
16778729 - Beyond cyclosporine: a systematic review of limited sampling strategies for other immun...
12535659 - Novel drug designing approach for dual inhibitors as anti-inflammatory agents: implicat...
17017939 - Phosphodiesterase 5 inhibitors--drug design and differentiation based on selectivity, p...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-21
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  26     ISSN:  1520-5827     ISO Abbreviation:  Langmuir     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16901-8     Citation Subset:  IM    
Biopharmaceutics and Pharmaceutical Technology, Campus A4 1, Saarland University, D-66123 Saarbruecken, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Energy transfer between surface-immobilized light-harvesting chlorophyll a/b complex (LHCII) studied...
Next Document:  Reactivity and selectivity in hydrovinylation of strained alkenes.