Document Detail


Multigenerational study of gold nanoparticles in Caenorhabditis elegans: Trans-generational effect of maternal exposure.
MedLine Citation:
PMID:  23590387     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this study, the generational transfer and multigenerational effect of gold nanoparticles (AuNPs) on Caenorhabditis elegans were investigated by observing the parental generation (F0) to the fourth offspring generation (F4) using food-exposure approaches. There were no significant changes on survival rate under all generation by AuNPs maternal exposure to the F0 generation. However, reproduction rate was clearly affected in the F2 generation, but then gradually recovered in the F3 and F4 generations. The abnormalities of reproductive system showed close relationship with reproduction rates. These phenomenons may be due to the germ-line transfer. The germ-line of F0 generation such as gonad and embryo germ cell may be affected during their development by maternal exposure of AuNPs, and this generation caused trans-generation effect on future generation. To the best of our knowledge, this is the first study to provide the evidence of trans-generational effects by maternal exposure of nanoparticles to the next generations.
Authors:
Shin Woong Kim; Jin Il Kwak; Youn-Joo An
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-16
Journal Detail:
Title:  Environmental science & technology     Volume:  -     ISSN:  1520-5851     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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