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Multigenerational mitochondrial alterations in pneumocytes exposed to oil fly ash metals.
MedLine Citation:
PMID:  21095158     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Oil fly ash (OFA), containing high amounts of transition metals, is among the most reactive airborne particulate matter emissions, which have been associated with several diseases, such as chronic obstructive pulmonary diseases (COPD), lung cancer, and cardiovascular diseases. The aim of the present study was to evaluate mitochondrial alterations in OFA-exposed cultured pneumocytes and in their progeny. Alveolar epithelial cells (A549 line) were exposed either to an OFA water solution, containing 68.8μM vanadium (V), 110.4μM iron (Fe), and 18.0μM nickel (Ni), or to the individual metal solutions. Structural and functional mitochondrial parameters were determined in exposed cultures and in 3 consecutive subcultures. OFA, V and Fe solutions caused a time-dependent loss of mitochondrial enzymatic activity, glutathione depletion, generation of lipid hydroperoxides, hydrogen peroxide and other reactive oxygen species, especially in G(0)-G(1) phase cells, accompanied by a decrease in mitochondrial mass and transmembrane potential. Mitochondrial alterations were partly transmissible to daughter cells for up to 3 generations. Fe and especially V were responsible for the observed mitochondrial alterations in pneumocytes exposed to OFA. Spread of mitochondrial dysfunctions to daughter cells is expected to amplify oxidative stress in the respiratory epithelium and to play an important role in the pathogenesis of respiratory diseases.
Authors:
Angela Di Pietro; Giuseppa Visalli; Barbara Baluce; Rosanna T Micale; Sebastiano La Maestra; Pasquale Spataro; Silvio De Flora
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Publication Detail:
Type:  Journal Article     Date:  2010-11-20
Journal Detail:
Title:  International journal of hygiene and environmental health     Volume:  214     ISSN:  1618-131X     ISO Abbreviation:  Int J Hyg Environ Health     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898843     Medline TA:  Int J Hyg Environ Health     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  138-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier GmbH. All rights reserved.
Affiliation:
Department of Hygiene, Public Health and Preventive Medicine, University of Messina, I-98100 Messina, Italy.
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