| Multigenerational effects of fetal dexamethasone exposure on the hypothalamic-pituitary-adrenal axis of first- and second-generation female offspring. | |
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MedLine Citation:
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PMID: 23220271 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Synthetic glucocorticoid (sGC) administration to women threatening preterm delivery increases neonatal survival. Evidence shows that fetal exposure to glucocorticoid levels higher than appropriate for current maturation programs offspring development. We examined fetal sGC multigenerational effects on F1 and F2 female offspring hypothalamo-pituitary-adrenal axis (HPAA) function. STUDY DESIGN: At 0.7 gestation, pregnant F0 ewes received 4 dexamethasone injections (2 mg, approximately 60 μg/kg(-1) per day(-1), 12 hours apart) or saline (control). F1 female offspring were bred to produce F2 female offspring. Postpubertal HPAA function was tested in F1 and F2 ewes. RESULTS: F1 and F2 ewe lambs showed reduced birthweight and morphometrics. Dexamethasone increased baseline but reduced stimulated HPAA activity in F1 and F2 female offspring. CONCLUSION: This is the first demonstration that sGC doses in the clinical range have multigenerational effects on hypothalamo-pituitary-adrenal activity in a precocial species, indicating the need for the study of long-term effects of fetal sGC exposure. |
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Authors:
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Nathan M Long; Stephen P Ford; Peter W Nathanielsz |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-12-07 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 208 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-25 Completed Date: 2013-04-23 Revised Date: 2013-05-16 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 217.e1-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2013 Mosby, Inc. All rights reserved. |
Affiliation:
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Center for the Study of Fetal Programming, University of Wyoming, Laramie, WY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dexamethasone / pharmacology* Female Glucocorticoids / pharmacology* Hypothalamo-Hypophyseal System / drug effects*, physiopathology Hypothalamus / drug effects, physiopathology Maternal-Fetal Exchange Pituitary Gland / drug effects, physiopathology Pituitary-Adrenal System / drug effects*, physiopathology Pregnancy Pregnancy, Animal* Prenatal Exposure Delayed Effects / physiopathology* Sheep |
| Grant Support | |
ID/Acronym/Agency:
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HD 21350/HD/NICHD NIH HHS; P01 HD021350/HD/NICHD NIH HHS; P20- RR-16474-04/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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