Document Detail


MULTIGATE QUALITY DOPPLER PROFILES AND MORPHOLOGICAL/HEMODYNAMIC ALTERATIONS IN MULTIPLE SCLEROSIS PATIENTS.
MedLine Citation:
PMID:  22475396     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Venous echo-color-Doppler (ECD) showed that chronic cerebrospinal venous insufficiency (CCSVI) syndrome is related to multiple sclerosis (MS). Study aims were to assess interobserver variability in ultrasound evaluation of MS patients and to relate echo-markers to MS clinical symptoms and disability degree. 277 MS patients (117 men, mean age 43.05±10.04 years) admitted to the Neurology Department of Bari University General Hospital, underwent to clinical, Expanded Disability Status Scale (EDSS) evaluation, and to a cerebro-venous system ECD evaluation. Two operators re-evaluate 32 patients to calculate interobserver variability. McNemar test confirmed the procedure reproducibility between two operators (p=ns). Septa/membranes correlated with deep cerebral veins reflux [right: absence 16% vs 58% presence, p<0.0001; left: 26% vs 50%, p<0.0001]; their absence to Primary Progressive (PP) MS form [right: 11% vs 2%, p<0.001; left: 12% vs 2%, p<0.001]. Internal jugular veins (IJVs) reflux absence was in Relapsing-remitting (RR) form [right: 60% vs 74%, p=0.036; left: 56% vs 85%, p<0.0001] like hemodinamically significant stenosis [right: 57% vs 69%, p=0.033; left: 49% vs 73%, p<0.001] not present in PP [right: 11% vs 2%, p<0.001; left: 10% vs 3%, p=0.009]. A supine IJVs blocked flow was related to EDSS class [right: 4.8±1.5 vs 5.4±1.4, p=0.006; left: 4.7±1.6 vs 5.5±1.2, p<0.0001]; its absence was linked to RR [right: 60% vs 76%, p=0.016; left: 58% vs 79%, p<0.001]. ECD has an important value in MS patients with IJV anomalies detection and a good interobserver procedure reproducibility. MS is associated to CCSVI, although further studies are needed.
Authors:
Marco Matteo Ciccone; Aldo Innocente Galeandro; Pietro Scicchitano; Annapaola Zito
Related Documents :
22648106 - The risk of postpolypectomy bleeding during colonoscopy in patients with early liver ci...
3148996 - Urinary protein excretion patterns in reactive (secondary) systemic amyloidosis.
19178816 - A novel method for the estimation of podocyte injury: podocalyxin-positive elements in ...
20814126 - Glomerular malondialdehyde levels in patients with focal and segmental glomeruloscleros...
18057286 - Transarterial chemoembolization for primary hepatocellular carcinoma in patients at hig...
1549056 - Prognosis of acute porphyria: occurrence of acute attacks, precipitating factors, and a...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-4
Journal Detail:
Title:  Current neurovascular research     Volume:  -     ISSN:  1875-5739     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208439     Medline TA:  Curr Neurovasc Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, piazza G. Cesare, 11, 70124 - Bari, Italy. ciccone@cardio.uniba.it.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  TEMPORAL PROGRESSION OF KAINIC ACID INDUCED CHANGES IN VASCULAR LAMININ EXPRESSION IN RAT BRAIN WITH...
Next Document:  SERUM BILIRUBIN AFTER ACUTE ISCHEMIC STROKE IS ASSOCIATED WITH STROKE SEVERITY.