| Multifunctional poly (lactide-co-glycolide) nanoparticles for luminescence/magnetic resonance imaging and photodynamic therapy. | |
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MedLine Citation:
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PMID: 22664459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly (lactide-co-glycolide) (PLGA) coupled with methoxy poly (ethylene glycol) (mPEG) or chlorin e6 (Ce6) was synthesized using the Steglich esterification method. PLGA-linked mPEG (PLGA-mPEG), PLGA-linked Ce6 (PLGA-Ce6), and Fe(3)O(4) were utilized to constitute multifunctional PLGA nanoparticles (∼160 nm) via the multi-emulsion W(1)/O/W(2) (water-in-oil-in-water) method. The photo-sensitizing properties of Ce6 molecules anchored to PLGA nanoparticles enabled in vivo luminescence imaging and photodynamic therapy for the tumor site. The encapsulation of Fe(3)O(4) allowed high contrast magnetic resonance (MR) imaging of the tumor in vivo. Overall, PLGA nanoparticles resulted in a significant tumor volume regression for the light-illuminated KB tumor in vivo and enhanced the contrast at the tumor region, compared to that of Feridex(®) (commercial contrast agent). |
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Authors:
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Dong Jin Lee; Ga Young Park; Kyung Taek Oh; Nam Muk Oh; Dong Sup Kwag; Yu Seok Youn; Young Taik Oh; Jin Woo Park; Eun Seong Lee |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2012-06-02 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 434 ISSN: 1873-3476 ISO Abbreviation: Int J Pharm Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-07-20 Completed Date: 2013-01-04 Revised Date: 2013-04-11 |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 257-63 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line, Tumor Dextrans / diagnostic use Female Ferric Compounds / diagnostic use Humans KB Cells Lactic Acid / chemistry* Luminescent Measurements / methods Magnetic Resonance Imaging / methods* Magnetite Nanoparticles / diagnostic use Mice Mice, Inbred BALB C Mice, Nude Nanoparticles* Neoplasms / diagnosis, pathology, therapy Photochemotherapy / methods* Photosensitizing Agents / administration & dosage, chemistry Polyethylene Glycols / chemistry Polyglactin 910 / chemistry Polyglycolic Acid / chemistry* Porphyrins / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Ferric Compounds; 0/Magnetite Nanoparticles; 0/Photosensitizing Agents; 0/Polyethylene Glycols; 0/Porphyrins; 0/poly(D,L-lactic-co-glycolic acid)-methoxy-poly(ethyleneglycol) copolymer; 0/polylactic acid-polyglycolic acid copolymer; 1309-37-1/ferric oxide; 19660-77-6/chlorin e6; 26009-03-0/Polyglycolic Acid; 34346-01-5/Polyglactin 910; 50-21-5/Lactic Acid; 9004-54-0/Dextrans; G6N3J05W84/ferumoxides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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